Connexin Antibody Explorer Kit

Connexin Antibody Explorer KitA Screening Package of Connexin Antibodies for Economically Priced
Cat #: AK-420
16 Vials

Alomone Labs is pleased to offer the Connexin Antibody Explorer Kit (#AK-420). This Explorer Kit includes connexin antibodies, ideal for screening purposes.

• Compounds
• Scientific Background

Product Name	Cat #	Size
Anti-Connexin-26	ACC-212	1 x 50 µl
Anti-Connexin-31	ACC-213	1 x 50 µl
Anti-Connexin-32	ACC-211	1 x 50 µl
Anti-Connexin-36	ACC-209	1 x 50 µl
Anti-Connexin-37	ACC-204	1 x 50 µl
Anti-Connexin-40	ACC-205	1 x 50 µl
Anti-Connexin-43	ACC-201	1 x 50 µl
Anti-Connexin-45	ACC-207	1 x 50 µl

Scientific Background Connexins (Cx) are integral membrane proteins consisting of four transmembrane domains, two extracellular loops, one intracellular loop and intracellular N- and C-termini. The 21 members belonging to this family form homomeric or heteromeric hexamers generally termed connexons or hemi-channels. In turn, these hemi-channels further assemble in a head-to-head manner, thus forming gap junction channels^1,2. Connexins are ubiquitously expressed and their activity is regulated at the expression level and by post-translational modifications¹. For example, Connexin-43 (Cx43) protein level is regulated by its turnover rate and by phosphorylation of various residues which ultimately determines its activity rate¹.
Connexin Antibody Explorer KitReferences 

1. Goodenough, D.A. and Paul, D.L. (2011) Cold Spring Harb. Persp. Biol. 2009, 1.
2. Nakagawa, S. et al. (2010) Curr. Opin. Struct. Biol. 20, 423.