Transcreener HTS Assays

• Four assays cover thousands of target enzymes, including any kinase, ATPase, or GTPase.
• Direct detection means less chance for compound interference.
• Far Red FP, FI and TR-FRET readouts validated on major multimode readers.
• Single step, mix and read format with 8 hour deck and signal stability for easy automation.

Thousands of cellular reactions use nucleotides, either alone or in combination with other substrates. Enzymes in the purinome alone – those that use adenine and guanine nucleotides – comprise 13% of the coding capacity of the human genome (ref). Of these, protein kinases have become highly validated drug targets, but lipid kinases, chaperone ATPases and GTPases as well as less obvious ATP-dependent enzymes such as Acetyl Co-A carboxylase are increasingly being targeted for therapeutic intervention.