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  • 徕卡抗体Anaplastic Lymphoma Kinase

    徕卡抗体Anaplastic Lymphoma Kinase

    产品信息

    Anaplastic large cell lymphoma (ALCL) is usually composed of largepleomorphic cells which are reported to express CD30 antigen and theepithelial membrane antigen (EMA).

      徕卡抗体Anaplastic Lymphoma Kinase
    Clone 4
    7 mL BOND ready-to-use PA0306 P (HIER)
    Antigen Background
    Anaplastic large cell lymphoma (ALCL) is usually composed of large
    pleomorphic cells which are reported to express CD30 antigen ａnd the
    epithelial membrane antigen (EMA). These tumor cells tend to occur in
    younger individuals ａnd may be associated with cutaneous ａnd extranodal
    involvement. A proportion of these cases contain a chromosomal
    translocation t(2;5) (p23; q35). This results in a hybrid gene encoding part of
    the nucleophosmin (NPM) gene joined to the cytoplasmic domain of the
    anaplastic lymphoma kinase (ALK) gene, giving rise to the protein, p80. Large
    cell lymphomas account for approximately 25 percent of all non-Hodgkin＇s
    lymphomas in children ａnd young adults, of which one third carries the NPMALK gene translocation.


    Human anaplastic lymphoma: immunohistochemical staining for anaplastic lymphoma
    kinase (p80) using NCL-ALK. Note cytoplasmic staining of large pleomorphic cells. Paraffin
    section.

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