Recombinant Human TNF-a Peprotech因子报价_详细资料

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生长因子此类产品包括人、小鼠或大鼠的细胞外蛋白，多数情况下可启始或影响通过细胞表面受体传递的信号。下列产品包括人、小鼠和大鼠的白细胞介素、集落刺激因子、生长因子、干扰素、脂肪因子、BMP蛋白、FGFs、TNFs、可溶性受体、细胞外结合蛋白、非抑制型丝氨酸蛋白酶抑制剂及其他免疫调节蛋白等。

Recombinant Human TNF-a Peprotech因子报价

产品编号:
300-01A
别名:
Tumor Necrosis Factor, TNFSF2, Cachectin, Differentiation-inducing factor (DIF), Necrosin, Cytotoxin
描述:
TNF-α is a pleiotropic pro-inflammatory cytokine secreted by various cells, including adipocytes, activated monocytes, macrophages, B cells, T cells ａnd fibroblasts. It belongs to the TNF family of ligands, ａnd signals through two receptors, TNFR1 ａnd TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells, ａnd is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, autoimmune diseases, rheumatoid arthritis, inflammation, ａnd diabetes. Human ａnd murine TNF-α demonstrate significant cross-species reactivity. TNF-α exists in two forms; a type II transmembrane protein, ａnd a mature soluble protein. The TNF-α transmembrane protein is proteolitically cleaved to yield a soluble, biologically active, 17 kDa TNF-α, which forms a non-covalently linked homotrimer in solution. Recombinant Human TNF-α is a soluble 157 amino acid protein (17.4 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.
氨基酸序列:
VRSSSRTPSD KPVAHVVANP QAEGQLQWLN RRANALLANG VELRDNQLVV PSEGLYLIYS QVLFKGQGCP STHVLLTHTI SRIAVSYQTK VNLLSAIKSP CQRETPEGAE AKPWYEPIYL GGVFQLEKGD RLSAEINRPD YLDFAESGQV YFGIIAL
来源:
E.coli
纯度:
Greater than 98% by SDS-PAGE gel ａnd HPLC analyses.
生物活性:
The ED₅₀ as determined by the cytolysis of murine L929 cells in the presence of Actinomycin D is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 10⁷ units/mg.

交叉反应:
Cow, Monkey, Mouse, Rat, Sheep, Human, Bacteria, Human + Rat, Pig, Dog, N/A, Human + Virus
研究领域:

AIDS/ HIV 血管生成/ 心血管

细胞凋亡癌症

糖尿病/ 体重调节免疫系统

炎症神经生物学

干细胞及分化 TNF超家族

过敏移植

原产国:
USA
仅用于研究。不适用于诊断或ZL。

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Recombinant Human TNF-a Peprotech因子报价

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	AIDS/ HIV		血管生成/ 心血管
	细胞凋亡		癌症
	糖尿病/ 体重调节		免疫系统
	炎症		神经生物学
	干细胞及分化		TNF超家族
	过敏		移植