代理Peprotech因子,Recombinant Murine IL-6 价格_详细资料

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代理Peprotech因子,Recombinant Murine IL-6 价格
Recombinant Murine IL-6
Catalog Number:
216-16
Synonyms:
26 kDa protein, IFN-b2, B cell differentiation factor （BCDF）, BSF-2, HPGF, HSF, MGI-2
Description:
IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune ａnd inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells ａnd keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation ａnd antibody production, synergizes with IL-3 in megakaryocyte development ａnd platelet production, induces expression of hepatic acute-phase proteins, ａnd regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α ａnd gp130. Murine IL-6 is inactive on human cells, while both human ａnd murine are equally active on murine cells. Recombinant murine IL-6 is a 21.7 kDa protein containing 188 amino acid residues.
AA Sequence:
MFPTSQVRRG DFTEDTTPNR PVYTTSQVGG LITHVLWEIV EMRKELCNGN SDCMNNDDAL AENNLKLPEI QRNDGCYQTG YNQEICLLKI SSGLLEYHSY LEYMKNNLKD NKKDKARVLQ RDTETLIHIF NQEVKDLHKI VLPTPISNAL LTDKLESQKE WLRTKTIQFI LKSLEEFLKV TLRSTRQT
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel ａnd HPLC analyses.
Biological Activity:
The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of IL-6-dependent murine 7TD1 cells is ≤ 0.02 ng/ml, corresponding to a specific activity of ≥ 5 x 10⁷ units/mg.

Cross Reactivity:
Monkey, Mouse, Trout, Rat, Mouse + Bacteria, Human + Mouse
Research Interests:

Angiogenesis/ Cardiovascular Cancer

Cell Culture Diabetes / Weight Regulation

Immune System Inflammation

Neurobiology Stem Cells & Differentiation

Wound Healing Allergy

Transplantation

Country of Origin:
USA

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	Transplantation