美国Peprotech细胞因子,Recombinant Human IGF-1_详细资料

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美国Peprotech细胞因子,Recombinant Human IGF-1北京杰辉生物销售标准品，对照品， ELISA kit，细胞因子，并提供ELISA实验代测服务，大量现货咨询电话：010- 56429247 ，半个个工作日之内给予答复。

美国Peprotech细胞因子,Recombinant Human IGF-1
Recombinant Human IGF-I
Catalog Number:
100-11
Synonyms:
Insulin-like Growth Factor-I, Somatamedin C, IGF-IA
Description:
The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation ａnd survival of various cell types including muscle, bone, ａnd cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin ａnd relaxin. The IGFs are similar by structure ａnd function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I ａnd IGF-II signal through the tyrosine kinase type I receptor （IGF-IR）, but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal ａnd C-terminal propeptide regions. Recombinant human IGF-I ａnd IGF-II are globular proteins containing 70 ａnd 67 amino acids, respectively, ａnd 3 intra-molecular disulfide bonds.
AA Sequence:
GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel ａnd HPLC analyses.
Biological Activity:
The ED₅₀ was determined by a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10⁵units/mg.

Cross Reactivity:
Bacteria, Chicken, Cow, Frog, Horse, Monkey, Mouse, Pig, Rat, Sheep, Tiger Salamander, Hamster, Human, N/A
Research Interests:

Angiogenesis/ Cardiovascular Bone, Skeletal, Cartilage

Diabetes / Weight Regulation Inflammation

Proliferation Wound Healing

Country of Origin:
USA

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	Angiogenesis/ Cardiovascular		Bone, Skeletal, Cartilage
	Diabetes / Weight Regulation		Inflammation
	Proliferation		Wound Healing