LAT Rabbit Antibody,LAT Rabbit Antibody 【产品介绍】LAT (linker f o r activation of T-cells) is involved in the T-cell antigen recept o r (TCR) signal transduction pathway, a n d may play an imp o r tant role downstream in activating protein tyrosine kinases (1). LAT is phosph o r ylated by ZAP-70/Syk protein tyrosine kinases leading to recruitment of multiple signaling molecules (2). It has been found that Tyr191 a n d Tyr171 are required f o r T-cell activation a n d Tyr132 is required f o r the activation of PLCgamma1 a n d Ras signaling pathways, respectively. Tyr226 a n d Tyr191 are required f o r Vav binding, whereas Tyr171 a n d Tyr132 are necessary f o r association a n d activation of phosphoinositide 3-kinase activity a n d PLCgamma1 (3). LAT Rabbit Antibody,LAT Rabbit Antibody WB: 1:500 IHC: 1:100 Flow Cytometry: 1:40 IP: 1:60 LAT Rabbit Antibody,LAT Rabbit Antibody A. Western blot analysis on Jurkat cell lysate using anti-LAT RabMAb (catalog #1499-1), dilution 1:500. B. Immunohistochemical analysis of paraffin-embedded human lymph node using anti-LAT RabMAb (catalog #1499-1). |