【产品介绍】The growth fact o r bound protein 2 (GRB2) is a 25 kDa cytosolic protein that contains one src homology (SH2) domain a n d two SH3 domains (1). GRB2 associates with Tyrosine phosph o r ylated EGFRs a n d PDGFRs via its SH2 domain. GRB2 also plays a crucial role in two separate insulin pathways leading from the insulin recept o r to the Ras protein thus affecting mitogenic signaling (2). Additionally GBR2, a bifunctional adapt o r protein, recruits Sos f o r Ras activation a n d subsequent signal transmission (3). GRB2 (C-term),Rabbit Monoclonal IgG WB: 1:5,000-10,000 IHC: 1:100-250 ICC: 1:50-100 IP: 1:50 GRB2 (C-term),Rabbit Monoclonal IgG A. Western blot analysis on 293 cell lysate using anti-GRB2 (C-term) RabMAb (catalog #1517-1), dilution 1:10,000. B. Immunohistochemical staining of paraffin-embedded human ovarian carcinoma using anti- GRB2 (C-term) RabMAb (catalog #1517-1). GRB2 (C-term),Rabbit Monoclonal IgG C. Immunoflu o r escent staining of HeLa cells using anti-GRB2 (C-term) RabMAb (catalog #1517-1). |