性 状: | 【反应特异性】Human , Mouse , Rat 【克隆 ID】Y423 Gab1 Rabbit Antibody,Rabbit Monoclonal 【用途】WB , ICC 【抗原分子量】76 kDa |
质量标准: | 【产品介绍】Gab1 (Grb2-associated binder-1) is an adapt o r protein that serves to activate numerous intracellular signaling pathways via its interaction with recept o r tyrosine kinases (RTKs). Gab1 is a substrate of various RTKs, including EGFR, insulin recept o r , cytokine recept o r s, a n d B cell antigen recept o r s; a n d it acts as a docking protein f o r several SH2-containing proteins (1-3). Tyrosine-phosph o r ylated Gab1 may recruit cytosolic signaling proteins to the cellular membrane, where they can act on membrane-bound targets as well as activate downstream pathways (4) Gab1 Rabbit Antibody,Rabbit Monoclonal WB: 1:1,000 IP: 1:50 A. Western blot analysis on 293 cell lysate using anti-Gab1 RabMAb (cat. #1626-1), dilution: 1:5,000. Gab1 Rabbit Antibody,Rabbit Monoclonal B. Immunoflu o r escent staining of PC-12 cells using anti-Gab-1 RabMAb (catalog #1626-1). |