性 状: | 【反应特异性】Human , Mouse , Rat E-Cadherin Phospho (pS838/840),Rabbit 【克隆 ID】EP913(2)Y 【用途】WB , IHC , ICC , IP 【抗原分子量】135 kDa |
质量标准: | 【产品介绍】E-Cadherin, a member of the cadherin superfamily, is implicated as a key player in different cellular processes including development, m o r phology, polarity, migration a n d tissue integrity (1-2). E-cadherin is a glycoprotein with an extracellular domain that interacts with other E-cadherin molecules on adjacent cells, thereby establishing adhesion between epithelial cells. Established as a tum o r a n d metastasis suppress o r , E-cadherin expression is frequently down-regulated o r extinguished in malignancy which strongly c o r relates with po o r prognosis (3-4). Mutations in E-cadherin are found in gastric, breast, col o r ectal, thyroid a n d ovarian cancer (5). E-Cadherin Phospho (pS838/840),Rabbit WB: 1:100,000 – 1,000,000 IHC: 1:100 – 250 ICC: 1:250 – 500 IP: 1:40 E-Cadherin Phospho (pS838/840),Rabbit A. Western blot analysis on human brain lysates using anti-Phospho-E-Cadherin (pS838/840) RabMAb (cat. #2239-1), 1:1,000,000 dilution. Cells were either (A) untreated (B) treated with AP B. Immunohistochemical analysis of paraffin-embedded human breast carcinoma using Phospho-anti-E-Cadherin RabMAb. (cat. #2239-1) E-Cadherin Phospho (pS838/840),Rabbit C. Immunohistochemical analysis of paraffin-embedded human cervical carcinoma using Phospho-E-Cadherin RabMAb.(cat.#2239-1). |