DAPK2 (N-term)，Rabbit Monoclonal IgG_详细资料

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DAPK2 (N-term)，Rabbit Monoclonal IgG【反应特异性】Human , Mouse , Rat【克隆 ID】EP1633Y【用途】WB , IHC , FC【抗原分子量】43 kDa

DAPK2 （N-term）
Rabbit Monoclonal IgG

Cas 号：

分子式：

别名： DAP kinase 2, DAP-kinase-related protein 1, DRP-1

订货信息：

货号品名规格包装单价货期订购

DAPK2 （N-term） 100g 询价现货订购

性状：
【反应特异性】Human , Mouse , Rat
DAPK2 （N-term），Rabbit Monoclonal IgG

【克隆 ID】EP1633Y
【用途】WB , IHC , FC
【抗原分子量】43 kDa

质量标准： 【产品介绍】Protein kinase termed death-associated
protein kinase 2 （DAPK2） dependant on calcium/
calmodulin （Ca2+/CaM） contains an N-terminal protein
kinase domain followed by a conserved CaM-binding
domain with significant homologies to those of DAP kinase,
a protein kinase involved in apoptosis. Overexpression
of DAPK2 significantly induced the m o r phological
changes characteristic of apoptosis. Results indicate
that DAPK2 is an additional member of DAP kinase
family involved in apoptotic signaling （1）. The region
of homology spans the catalytic domain a n d the
CaM-regulat o r y region, whereas the remaining
C-terminal part of the protein differs completely from
DAP kinase a n d displays no homology to any known
protein. The catalytic domain is also homologous to
the recently identified ZIP kinase a n d to a lesser
extent to the catalytic domains of DRAK1 a n d -2 （2）.
DAPK2 has a novel regulat o r y mechanism that controls
its pro-apoptotic functions. It comprises a
single autophosph o r ylation event mapped to Ser308
within the CaM regulat o r y domain. A negative charge
at this site reduces both the binding to CaM a n d the
f o r mation of DRP-1 homodimers （3）.

DAPK2 （N-term），Rabbit Monoclonal IgG
WB: 1:2000
IHC: 1:50 100
Flow Cytometry: 1:15

A. Western blot analysis on rat spleen lysate
using anti-DAPK2 RabMAb （cat. # 2009-1）, dilution 1:2000.

DAPK2 （N-term），Rabbit Monoclonal IgG

B. Immunohistochemical staining of paraffin-embedded
human liver carcinoma using anti-DAPK2 RabMAb （cat. #2009-1）.

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DAPK2 (N-term)，Rabbit Monoclonal IgG

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货号	品名	规格	包装	单价	货期	订购
	DAPK2 （N-term）		100g	询价	现货	订购