| 性 状： | 【反应特异性】Human
【克隆 ID】EP1628Y
Cytokeratin 8，Rabbit Monoclonal IgG 【用途】WB , IHC , ICC , FC , IP
【抗原分子量】52 kDa |
| 质量标准： | 【产品介绍】Keratins, the intermediate filament proteins
of epithelial cells, connect to desmosomes, the
cell-cell adhesion structures at the surface membrane.
Among the various intermediate filament （IF）
proteins, cytokeratin 8 （CK8） is especially remarkable as
it is produced early in embryogenesis, is the only
type-II CK occurring in many simple epithelial cells,
a n d can also be synthesized in certain
non-epithelial cells （1）. Keratin 8 a n d 18 （CK8/18）
are the maj o r keratin pair in simple-type epithelia,
as found in the liver, pancreas, a n d intestine （2）.
While K8/K18 are essential f o r maintaining
structural integrity, there is accumulating
evidence indicating that they also exert
non-mechanical functions. It has been rep o r ted
that K8/K18-free hepatocytes from K8-null mice are
m o r e sensitive to Fas-mediated apoptosis, in line with
an increased Fas density at the cell surface a n d
an altered c-Flip regulation of the anti-apoptotic
ERK1/2 signaling pathway （3）. Cytokeratin 8，Rabbit Monoclonal IgG
WB: 1:25,000 50,000
IHC: 1:250 500
ICC: 1:100 250
Flow Cytometry: 1:20
IP: 1:70 Cytokeratin 8，Rabbit Monoclonal IgG A. Western blot analysis on A431 cell lysate using
anti-CK8 RabMAb（cat. # 2032-1）, dilution 1:50,000. B. Immunohistochemical analysis of paraffin-embedded
human breast adenocarcinoma using anti-CK8
RabMAb （cat. #2032-1）. |
Cytokeratin 8，Rabbit Monoclonal IgG
Cytokeratin 13 Rabbit Monoclonal Antibody
Cytokeratin 20 Rabbit Monoclonal Antibody
Cytokeratin 4 Rabbit Monoclonal Antibody
沪公网安备 31011502008050号
