质量标准: | 【产品介绍】CrkL (Crk-like), a 36kDa protein predominantly expressed in hematopoietic cell lines, is a member of the Crk adapter protein family. Lacking any intrinsic enzymatic activity, CrkL is composed of one SH2 domain a n d two SH3 domains (1). The SH2 domain of CrkL as been shown to interact with c-Cbl, Cas, Hef-1 a n d Paxillin (2); while the N-terminal SH3 can bind to c-ABL, Sos1 a n d C3G (3). Additionally, the phosph o r ylated f o r m of CrkL (pY207) binds to BCr-ABL oncogene in chronic myelogenous leukemia cells (4). CrkL Phospho(pY207),Rabbit Monoclonal WB: 1:50,000 IP: 1:50 CrkL Phospho(pY207),Rabbit Monoclonal A. Western blot analysis on K562 cell lysates using anti-Phospho-CrkL (pT207) RabMAb (cat. #1888-1), 1:50,000 dilution. Cells were either (A) untreated (B) treated with AP |