【产品介绍】Bid, BH3 interacting domain death agonist, is a pro-apoptotic member of the Bcl-2 family of proteins that regulate apotosis. Bid is localized to the cytosol in an inactive precurs o r f o r m. Upon caspase-8 binding in the Fas signaling pathway, Bid is cleaved a n d the active Bid fragment translocates to mitochondria a n d induces cytochrome c release a n d the resulting apoptotic cascade (1-3). Bid contains a BH3 domain which allows it to dimerize with a n d counter the death repress o r effects of Bcl-2. BID has also been shown to heterodimerize with Bcl-x a n d the death agonist Bax (4). Bid Rabbit Antibody,Rabbit Monoclonal WB: 1:1,000 IHC: 1:100 ICC: 1:100 Flow Cytometry: 1:50 IP: 1:10 Bid Rabbit Antibody,Rabbit Monoclonal A. Western blot analysis of Jurkat cell lysate using anti Bid RabMAb catalog# 1008 -1 Bid Rabbit Antibody,Rabbit Monoclonal B. Immunohistochemical analysis of paraffin-embedded human prostate carcinoma using anti-Bid RabMAb (catalog # 1008-1). |