Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer´s disease. Alternatively s
【中文名称】:突触核蛋白α (phospho Tyr125) 多克隆抗体
【英语名称】:Synuclein-α (phospho Tyr125) Polyclonal Antibody
【产品类型】:一抗
【供应商】:Abbkine
【产品货号】:ABP50530
【产品规格】:30u/100ul/200ul
【背景资料】:Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer´s disease. Alternatively spliced transcripts encoding different isoforms have been identified for SNCA. 蛋白别名为:SNCA; NACP; PARK1; Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP;基因ID为:6622;蛋白质ID:P37840
【应用类型】:WB,IHC-p,ELISA补充:的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: IHC-p: 1:100-1:300, ELISA: 1:20000. Not yet tested in other applications.
【免疫原】:合成多肽:human Synuclein-α around the phosphorylation site of Y125.
【来源宿主】:兔
【反应性】:人,小鼠,大鼠
【保存建议】:厂家推荐蓝冰运输.在发货后能在-20℃保存1年.为限度的避免损失,请在打开管盖之前融化抗体并离心.我们建议使用前分装以避免反复冻融.本产品为液体形式,溶解于PBS缓冲液中,含50%甘油,0.5%BSA和0.02%叠氮化钠.
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