ERBB3 encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation
【中文名称】:受体酪氨酸受体激酶ErbB3 (phospho Tyr1328) 多克隆抗体
【英语名称】:ErbB-3 (phospho Tyr1328) Polyclonal Antibody
【产品类型】:一抗
【供应商】:Abbkine
【产品货号】:ABP54153
【产品规格】:30u/100ul/200ul
【背景资料】:ERBB3 encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. 蛋白别名为:ERBB3; HER3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3;基因ID为:2065;蛋白质ID:P21860
【应用类型】:IHC-p,ELISA补充:的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: IHC-p: 1:100-1:300, ELISA: 1:5000. Not yet tested in other applications.
【免疫原】:合成多肽:human ErbB-3 around the phosphorylation site of Y1328.
【来源宿主】:兔
【反应性】:人,小鼠,大鼠
【保存建议】:厂家推荐蓝冰运输.在发货后能在-20℃保存1年.为限度的避免损失,请在打开管盖之前融化抗体并离心.我们建议使用前分装以避免反复冻融.本产品为液体形式,溶解于PBS缓冲液中,含50%甘油,0.5%BSA和0.02%叠氮化钠.
【产品说明】:点击:受体酪氨酸受体激酶ErbB3 (phospho Tyr1328) 多克隆抗体查看更详细产品说明,更多应用、储存、价格、货期等信息请致电垂询AbbkineZG区域授权总代理艾美捷科技有限公司。更多特色试剂盒、特色抗体以及特色试剂等产品评论,请点击查看每日生物评论网站。
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