Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. BCAR3 (breast cancer anti-estrogen resistance 3)encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in huma
【中文名称】:乳腺癌抗雌激素抗性蛋白3 多克隆抗体
【英语名称】:BCAR3 Polyclonal Antibody
【产品类型】:一抗
【供应商】:Abbkine
【产品货号】:ABP56732
【产品规格】:30u/100ul/200ul
【背景资料】:Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. BCAR3 (breast cancer anti-estrogen resistance 3)encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for BCAR3.蛋白别名为:BCAR3; NSP2; SH2D3B; Breast cancer anti-estrogen resistance protein 3; Novel SH2-containing protein 2; SH2 domain-containing protein 3B;基因ID为:8412;蛋白质ID:O75815
【应用类型】:WB,IHC-p,IF,ELISA补充:的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, IHC-p: 1:100-1:300, IF: 1:200-1:1000, ELISA: 1:10000. Not yet tested in other applications.
【免疫原】:合成多肽:the C-terminal region of human BCAR3. at AA rangle: 730-810
【来源宿主】:兔
【反应性】:人
【保存建议】:厂家推荐蓝冰运输.在发货后能在-20℃保存1年.为限度的避免损失,请在打开管盖之前融化抗体并离心.我们建议使用前分装以避免反复冻融.本产品为液体形式,溶解于PBS缓冲液中,含50%甘油,0.5%BSA和0.02%叠氮化钠.
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