The serine-threonine protein kinase encoded by the AKT1(AKT serine/threonine kinase 1) gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator
【中文名称】:丝氨酸/苏氨酸激酶AKT 小鼠单克隆抗体(1H2)
【英语名称】:AKT Mouse Monoclonal Antibody(1H2)
【产品类型】:一抗
【供应商】:Abbkine
【产品货号】:ABM40276
【产品规格】:30u/100ul/200ul
【背景资料】:The serine-threonine protein kinase encoded by the AKT1(AKT serine/threonine kinase 1) gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in AKT1 have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for AKT1.蛋白别名为:AKT1;基因ID为:207;蛋白质ID:P31749
【应用类型】:WB,IHC-p补充:的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:1000-2000, IHC-p: 1:100-200.
【免疫原】:合成多肽 of AKT at AA range of 400-480
【来源宿主】:小鼠
【反应性】:人
【保存建议】:厂家推荐蓝冰运输.在发货后能在-20℃保存1年.为限度的避免损失,请在打开管盖之前融化抗体并离心.我们建议使用前分装以避免反复冻融.本产品为液体形式,溶解于PBS缓冲液中,含50%甘油,0.5%BSA和0.02%叠氮化钠.
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