乙酰化Lys proteins 多克隆抗体Acetyl Lys proteins Polyclonal Antibody

【中文名称】：乙酰化Lys proteins 多克隆抗体

【英语名称】：Acetyl Lys proteins Polyclonal Antibody

【产品类型】：一抗

【供应商】：Abbkine

【产品货号】：ABP53385

【产品规格】：30u/100ul/200ul

【背景资料】：The nucleosome, made up of four core histone proteins (H2A, H2B, H3, and H4), is the primary building block of chromatin. Originally thought to function as a static scaffold for DNA packaging, histones have now been shown to be dynamic proteins, undergoing multiple types of post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination (1,2). Histone acetylation occurs mainly on the amino-terminal tail domains of histones H2A (Lys5), H2B (Lys5, 12, 15, and 20), H3 (Lys9, 14, 18, 23, 27, 36 and 56), and H4 (Lys5, 8, 12, and 16) and is important for the regulation of histone deposition, transcriptional activation, DNA replication, recombination, and DNA repair (1-3). Hyper-acetylation of the histone tails neutralizes the positive charge of these domains and is believed to weaken histone-DNA and nucleosome-nucleosome interactions, thereby destabilizing chromatin structure and increasing the accessibility of DNA to various DNA-binding proteins (4,5). In addition, acetylation of specific lysine residues creates docking sites for a protein module called the bromodomain, which binds to acetylated lysine residues (6). Many transcription and chromatin regulatory proteins contain bromodomains and may be recruited to gene promoters, in part, through binding of acetylated histone tails. Histone acetylation is mediated by histone acetyltransferases (HATs), such as CBP/p300, GCN5L2, PCAF, and Tip60, which are recruited to genes by DNA-bound protein factors to facilitate transcriptional activation (3). Deacetylation, which is mediated by histone deacetylases (HDAC and sirtuin proteins), reverses the effects of acetylation and generally facilitates transcriptional repression (7,8).Histone H4 lysine 5 is acetylated by multiple HAT proteins. Acetylation by Esa1p in yeast, or Tip60 in mammalian cells, may contribute to both transcriptional activation and DNA repair, including non-homologous end joining and replication-coupled repair (9-12). Histone H4 lysine 5 is also acetylated by CBP/p300, a family of HAT proteins that function as transcriptional co-activators for a large number of transcription factors (13).

【应用类型】：WB，IHC-p，IF，ELISA补充：的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, IHC-p: 1:100-1:300, IF: 1:200-1:1000, ELISA: 1:10000. Not yet tested in other applications.

【免疫原】：合成多肽：human acetylation Lys proteins.

【来源宿主】：兔

【反应性】：人，小鼠，大鼠，猴

【保存建议】：厂家推荐蓝冰运输.在发货后能在-20℃保存1年.为限度的避免损失，请在打开管盖之前融化抗体并离心.我们建议使用前分装以避免反复冻融.本产品为液体形式,溶解于PBS缓冲液中，含50%甘油，0.5%BSA和0.02%叠氮化钠.

【产品说明】：点击：乙酰化Lys proteins 多克隆抗体查看更详细产品说明，更多应用、储存、价格、货期等信息请致电垂询AbbkineZG区域授权总代理艾美捷科技有限公司。更多特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看每日生物评论网站。

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