The protein encoded by SMAD2(SMAD family member 2) belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene ´mothers against decapentaplegic´ (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis
艾美捷科技有限公司,目前提供Abbkine高质量抗体:信号传导蛋白SMAD2 多克隆抗体,性价比非常高。Abbkine致力于为生命科学研究和YL发展提供的产品和技术。Abbkine设计、开发、生产并销售了一系列独特的产品,包括生命科学领域研究相关的抗体、研究试剂以及细胞功能分析产品。Abbkine的产品为科学研究中的挑战提供卓有成效的解决方案,从而为的科学家节省时间并提高研究效率。作为Abbkine的ZG区域总代理,艾美捷科技有限公司凭借丰富的专业经验,将一如既往的为ZG区域客户提供Abbkine优质的产品和技术服务。
【英文名称】:Smad2 Polyclonal Antibody
【中文名称】:信号传导蛋白SMAD2 多克隆抗体
【产品类型】:一抗
【供应商】:Abbkine
【产品货号】:ABP57271
【背景资料】:The protein encoded by SMAD2(SMAD family member 2) belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene ´mothers against decapentaplegic´ (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for SMAD2.蛋白别名为:SMAD2; MADH2; MADR2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2;基因ID为:4087;蛋白质ID:Q15796
【产品规格】:30u/100ul/200ul
【应用类型】:WB补充:的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, ELISA: 1:10000. Not yet tested in other applications.
【免疫原】:合成多肽:human Smad2 around the non-phosphorylation site of S465.
【来源宿主】:兔
【反应性】:人
【保存建议】:厂家推荐蓝冰运输.在发货后能在-20℃保存1年.为限度的避免损失,请在打开管盖之前融化抗体并离心.我们建议使用前分装以避免反复冻融.本产品为液体形式,溶解于PBS缓冲液中,含50%甘油,0.5%BSA和0.02%叠氮化钠.
【产品说明】:点击:信号传导蛋白SMAD2 多克隆抗体查看更详细产品说明,更多应用、储存、价格、货期等信息请致电垂询AbbkineZG区域授权总代理艾美捷科技有限公司。更多特色试剂盒、特色抗体以及特色试剂等产品评论,请点击查看每日生物评论网站。
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