皮层蛋白 多克隆抗体Cortactin (Acetyl Lys235) Polyclonal Antibody

艾美捷科技有限公司，目前提供Abbkine高质量抗体:皮层蛋白 多克隆抗体，性价比非常高。Abbkine致力于为生命科学研究和YL发展提供的产品和技术。Abbkine设计、开发、生产并销售了一系列独特的产品，包括生命科学领域研究相关的抗体、研究试剂以及细胞功能分析产品。Abbkine的产品为科学研究中的挑战提供卓有成效的解决方案，从而为的科学家节省时间并提高研究效率。作为Abbkine的ZG区域总代理，艾美捷科技有限公司凭借丰富的专业经验，将一如既往的为ZG区域客户提供Abbkine优质的产品和技术服务。

【英文名称】：Cortactin Polyclonal Antibody

【中文名称】：皮层蛋白 多克隆抗体

【产品类型】：一抗

【供应商】：Abbkine

【产品货号】：ABP53756

【背景资料】：This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]CTTN (Cortactin) is a Protein Coding gene. Diseases associated with CTTN include ampulla of vater adenocarcinoma and ethmoid sinus cancer. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include profilin binding. An important paralog of this gene is DBN1.Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454).蛋白别名为：CTTN; EMS1; Src substrate cortactin; Amplaxin; Oncogene EMS1;基因ID为：13043；蛋白质ID:Q14247

【产品规格】：30u/100ul/200ul

【应用类型】：WB，IHC-p，IF，ELISA补充：的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, IHC-p: 1:100-1:300, IF: 1:200-1:1000, ELISA: 1:20000. Not yet tested in other applications.

【免疫原】：合成多肽：human Cortactin around the non-phosphorylation site of Y466.

【来源宿主】：兔

【反应性】：人，小鼠，大鼠，猴

【保存建议】：厂家推荐蓝冰运输.在发货后能在-20℃保存1年.为限度的避免损失，请在打开管盖之前融化抗体并离心.我们建议使用前分装以避免反复冻融.本产品为液体形式,溶解于PBS缓冲液中，含50%甘油，0.5%BSA和0.02%叠氮化钠.

【产品说明】：点击：皮层蛋白 多克隆抗体查看更详细产品说明，更多应用、储存、价格、货期等信息请致电垂询AbbkineZG区域授权总代理艾美捷科技有限公司。更多特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看每日生物评论网站。

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