Anti-BAAT antibody，长链脂肪酸酰基辅酶A水解酶抗体_详细资料

产品信息 Anti-BAAT antibody，长链脂肪酸酰基辅酶A水解酶抗体，应用于IHC、WB、 IF、IP、ELISA等实验，公司生产的抗体每个流程都执行严格的检测标准，保证蛋白抗原产品质量，质量稳定，实验效果明显。按理化性质和生物学功能，可将其分为IgM、IgG、IgA、IgE、IgD五类。公司产品经无数次市场验证，若出 产品编号Rs-5040R 英文名称BAAT 中文名称长链脂肪酸酰基辅酶A水解酶抗体 别名BACAT; BAT; Bile acid CoA:amino acid N acyltransferase; Bile acid Coenzyme A amino acid N acyltransferase glycine N choloyltransferase ; Bile acid Coenzyme A: amino acid N acyltransferase; Glycine N choloyltransferase; Long chain fatty acyl CoA hydrolase; MGC104432; FLJ20300; BAAT; BAAT_HUMAN; Bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase); Bile acid Coenzyme A amino acid N acyltransferase glycine N choloyltransferase. 说明书0.2ml 研究领域肿瘤细胞生物免疫学转录调节因子转运蛋白 抗体来源Rabbit 克隆类型Polyclonal 交叉反应Human, Mouse, Rat, Horse, Rabbit, 产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量46kDa 性状Lyophilized or Liquid 浓度1mg/1ml 免疫原KLH conjugated synthetic peptide derived from human BAAT 亚型IgG 纯化方法affinity purified by Protein A 储存液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 ａnd 50% Glycerol. 保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMedPubMed 产品介绍background: BAAT (bile acid Coenzyme A: amino acid N-acyltransferase) is involved in bile acid metabolism. In liver hepatocytes BAAT catalyzes the transfer of the bile acid moiety from the acyl-CoA thioester to glycine ａnd taurine, before excretion into bile canaliculi. This is the second step in the formation of bile acid-amino acid conjugates. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid ａnd fat-soluble vitamin absorption. BAAT may also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. Function: Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine ａnd taurine before excretion into bile canaliculi. The major components of bile are cholic acid ａnd chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid ａnd fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine ａnd are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- ａnd very long-chain saturated acyl-CoAs to the free fatty acid ａnd coenzyme A (CoASH), ａnd conjugates glycine to these acyl-CoAs. Subcellular Location: Cytoplasm. Tissue Specificity: Expressed in liver, gallbladder mucosa ａnd pancreas. DISEASE: Defects in BAAT are involved in familial hypercholanemia (FHCA) [MIM:607748]. FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, ａnd fat malabsorption. Similarity: Belongs to the C/M/P thioester hydrolase family. Database links: Entrez Gene: 570 Human Entrez Gene: 12012 Mouse Entrez Gene: 29725 Rat Omim: 602938 Human SwissProt: Q14032 Human SwissProt: Q91X34 Mouse SwissProt: Q63276 Rat Unigene: 284712 Human Unigene: 2859 Mouse Unigene: 11129 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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Anti-BAAT antibody，长链脂肪酸酰基辅酶A水解酶抗体

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