芳香化酶（抗原） 多肽

Overview

• Product nameAromatase peptideSee all Aromatase products （ 6 ） ...
• Protein descriptionThis peptide was used as an immunogen for ab18995 - Aromatase antibody.

  Properties

• Purity> 90 % by SDS-PAGE
• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot ａnd store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.02% Thimerosal （merthiolate）
  Constituents: 0.1% BSA, PBS, pH 7.2
• Concentration 50 µg at 0.2 mg/ml
  
  Concentration information loading...
• Research Areas
  • Metabolism
  • Pathways ａnd Processes
  • Metabolic signaling pathways
  • Lipid ａnd lipoprotein metabolism
  • Lipid metabolism

  • Metabolism
  • Pathways ａnd Processes
  • Endocrine metabolism
  • Hormone biosynthesis

  • Metabolism
  • Types of disease
  • Cancer

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Hormone biosynthesis

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Metabolism of lipids ａnd lipoproteins

  • Epigenetics ａnd Nuclear Signaling
  • Nuclear Signaling Pathways
  • Nuclear Receptors
  • Estrogen

  • Neuroscience
  • Endocrine system
  • Gonadotrophic axis

  • Cell Biology
  • Cell Cycle
  • Cell differentiation

Applications

• Application notesBL: Use at an assay dependent dilution.
  
  It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30 minutes at 37°C
  
  This peptide can be used with studies using ab18995.
  
  
  Not yet tested in other applications.
  Optimal dilutions/concentrations should be determined by the end user.

Protein info

• Alternative names
  AROARO 1ARO1

  ARO1AromataseCP19A_HUMANCPVCPV1CYARCYP19CYP19A1CYPXIXCytochrome P-450AROMCytochrome P450 19A1Cytochrome P450 family 19 subfamily A polypeptide 1Cytochrome P450, family 19, subfamily A, polypeptide 1Cytochrome P450, subfamily XIX （aromatization of androgens）Estrogen synthaseEstrogen synthetaseFlavoprotein linked monooxygenaseMGC104309Microsomal monooxygenaseOTTHUMP00000162543OTTHUMP00000198350P 450AROMP450AROM

  see all

• FunctionCatalyzes the formation of aromatic C18 estrogens from C19 androgens.
• Tissue specificityBrain, placenta ａnd gonads.
• Involvement in diseaseDefects in CYP19A1 are a cause of aromatase excess syndrome （AEXS） [MIM:139300]; also known as familial gynecomastia. AEXS is characterized by an estrogen excess due to an increased aromatase activity.
  Defects in CYP19A1 are the cause of aromatase deficiency （AROD） [MIM:107910]. AROD is a rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In adult females, manifestations include delay of puberty, breast hypoplasia ａnd primary amenorrhoea with multicystic ovaries.
• Sequence similaritiesBelongs to the cytochrome P450 family.