Anti-eIF3F真核翻译起始因子3F抗体

本公司经销eIF3F，真核翻译起始因子3F抗体，克隆类型为polyclonal，宿主来源是Rabbit，eIF3F真核翻译起始因子3F抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-3841R
英文名称：Anti-eIF3F
中文名称：真核翻译起始因子3F抗体
其他名称：名eIF 3 epsilon; eIF3 p47; eIF3 p47 subunit; EIF3S5; Eukaryotic translation initiation factor 3 subunit 5; Eukaryotic translation initiation factor 3 subunit F; translation initiation factor 3 47 kda subunit; EIF3F_HUMAN.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 38kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, hrs, chk, dog, cow
产品介绍：EIF3F, （also known as eukaryotic translation initiation factor 3 subunit 5, EIF-3 epsilon, ａnd EIF3 p47 subunit）, is part of the EIF3 complex, which is composed of at least 12 subunits. It binds the 40S ribosome ａnd promotes the binding of methionyl-tRNAi ａnd mRNA. It can bind the COP9 signalosome ａnd the 26S proteasome, possibly having regulatory functions in both protein translation ａnd degradation. EIF3F also associates with the complex p170-EIF3.Function : Component of the eukaryotic translation initiation factor 3 （eIF-3） complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome ａnd facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi ａnd eIF-5 to form the 43S preinitiation complex （43S PIC）. The eIF-3 complex stimulates mRNA recruitment to the 43S PIC ａnd scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly ａnd recycling of post-termination ribosomal complexes ａnd subsequently prevents premature joining of the 40S ａnd 60S ribosomal subunits prior to initiation.Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling.Subunit : Component of the eukaryotic translation initiation factor 3 （eIF-3） complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L ａnd EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G ａnd EIF3I; module B is composed of EIF3F, EIF3H, ａnd EIF3M; ａnd module C is composed of EIF3C, EIF3D, EIF3E, EIF3K ａnd EIF3L. EIF3C of module C binds EIF3B of module A ａnd EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding ａnd activation of a complex composed of MTOR ａnd RPTOR, leading to phosphorylation ａnd release of RPS6KB1 ａnd binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner. Interacts with DTX1, the interaction is required for deubiquitinating activity towards NOTCH1.Subcellular Location : Cytoplasm.Post-translational modifications : Phosphorylated. Phosphorylation is enhanced upon serum stimulation.Similarity : Belongs to the eIF-3 subunit F family.Contains 1 MPN （JAB/Mov34） domain.