本公司经销phospho-CREB-1(Ser129),磷酸化CREB-1抗体,克隆类型为polyclonal,宿主来源是Rabbit,phospho-CREB-1(Ser129)磷酸化CREB-1抗体可应用于WB、elisa、IP、IF、IHC等实验,欢迎垂询订购!
本公司经销phospho-CREB-1(Ser129),磷酸化CREB-1抗体,克隆类型为polyclonal,宿主来源是Rabbit,phospho-CREB-1(Ser129)磷酸化CREB-1抗体可应用于WB、elisa、IP、IF、IHC等实验,欢迎垂询订购!
货号:BY-5256R
英文名称:Anti-phospho-CREB-1(Ser129)
中文名称:磷酸化CREB-1抗体
其他名称:CREB(Phospho-Ser129); p-CREB-1(Ser129); pCREB-1(Ser129); Active transcription factor CREB; cAMP response element binding protein; cAMP responsive element binding protein 1; CREB1; CREB 1; CREB1; MGC9284; Transactivator protein; CREB.
抗体来源:Rabbit
克隆类型:polyclonal
蛋白分子量:predicted molecular weight: 43kDa
纯化方法:affinity purified by Protein A
交叉反应:hu, rat, mo
产品介绍:The ATF/CREB family consists of transcription factors that function through binding to the cAMP responsive element (CRE) palindromic octanucleotide, TGACCTCA. The best characterized members of this gene family include CREB-1, CREB-2, ATF-1,ATF-2,ATF-3and ATF-4. these transcription factors share highly-related COOH terminal leucine zipper demerization and basic DNA bindings but are highly divergent in their amino terminal domains. Although each of the ATF/CREB proteins bind CREs in their homodimeric form, in cerain instances they also bind as heterodimers, both within the ATF/CREB family and with members of the AP-1 transcription factor family. It has recentlybeen shown that protein kinase A-mediated CREB phosphorylation results in its binding to a 265kDa nuclear protein designated CBP (CREB-binding protein), which may reprecent a CREB co-activator.Function : This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.Subcellular Location : Nucleus.Post-translational modifications : Stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.Sumoylated by SUMO1. Sumoylation on Lys-304, but not on Lys-285, is required for nuclear localization of this protein. Sumoylation is enhanced under hypoxia, promoting nuclear localization and stabilization.DISEASE : Defects in CREB1 may be a cause of angiomatoid fibrous histiocytoma (AFH) [MIM:612160]. A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. Note=A chromosomal aberration involving CREB1 is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(2;22)(q33;q12) with CREB1 generates a EWSR1/CREB1 fusion gene that is most common genetic abnormality in this tumor type.Similarity : Belongs to the bZIP family.Contains 1 bZIP domain.Contains 1 KID (kinase-inducible) domain.