Anti-CPB2/Carboxypeptidase B2胰羧肽酶B2抗体

本公司经销CPB2/Carboxypeptidase B2，胰羧肽酶B2抗体，克隆类型为polyclonal，宿主来源是Rabbit，CPB2/Carboxypeptidase B2胰羧肽酶B2抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-7547R
英文名称：Anti-CPB2/Carboxypeptidase B2
中文名称：胰羧肽酶B2抗体
其他名称：Carboxypeptidase B like protein; Carboxypeptidase U; CarboxypeptidaseB2; Carboxypeptidase B2; CarboxypeptidaseU; CP B2; CPB 2; CPB2; CPU; PCPB; Plasma carboxypeptidase B; Plasma carboxypeptidase B2; Procarboxypeptidase B; Procarboxypeptidase R; Procarboxypeptidase U; TAFI; Thrombin activable fibrinolysis inhibitor; Thrombin activatable fibrinolysis inhibitor.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 36kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, hrs, cow
产品介绍：This protein belongs to a family of Zn-containing metallocarboxypeptidases specific to C-terminal lysine ａnd arginine residues. It circulates in plasma as a zymogen with molecular weight of 55 kDa （401 amino acid residues; pI 5.0）. Being activated by thrombin-thrombomodulin complex during blood coagulation, it exerts carboxypeptidase activity. Activated carboxypeptidase B2 removes C-terminal lysine residues from fibrin, which is necessary for plasminogen binding to fibrin. This prevents plasminogen from activation into plasmin ａnd retards the lysis of a fibrin clot. The concentration in plasma of healthy people is 5-10 ug/ml. High plasma levels were found in patients with stable angina pectoris ａnd angiographically verified coronary artery disease. Elevated concentration in blood is considered as a risk factor for venous thrombosis. A deficiency might contribute to the severity of bleeding disorders in hemophilias A ａnd B, ａnd decreased levels are found in chronic liver disease.Function : Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.Subcellular Location : SecretedTissue Specificity : Plasma; synthesized in the liver.Similarity : Belongs to the peptidase M14 family.