Anti-Phospho-mTOR (Thr2446)磷酸化雷帕霉素靶蛋白抗体

本公司经销Phospho-mTOR （Thr2446），磷酸化雷帕霉素靶蛋白抗体，克隆类型为polyclonal，宿主来源是Rabbit，Phospho-mTOR （Thr2446）磷酸化雷帕霉素靶蛋白抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-5331R
英文名称：Anti-Phospho-mTOR （Thr2446）
中文名称：磷酸化雷帕霉素靶蛋白抗体
其他名称：名Mammalian target of rapamycin; FKBP12 rapamycin associated protein; FK506 binding protein 12 rapamycin associated protein 1; FK506 binding protein 12 rapamycin associated protein 2; FKBP rapamycin associated protein; FKBP12 rapamycin complex associated protein; FRAP; FRAP1; FRAP2; Mammalian target of rapamycin; MTOR; RAFT1; Rapamycin associated protein FRAP2; Rapamycin target protein; RAPT1; flat.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 280kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, Rb, shp, hrs, dog
产品介绍：mTOR is one of a family of proteins involved in cell cycle progression, DNA recombination, ａnd DNA damage detection. In rat, it is a 289-kDa protein （symbolized RAFT1） with significant homology to the Saccharomyces cerevisiae protein TOR1 ａnd has been shown to associate with the immunophilin FKBP12 in a rapamycin dependent fashion. The FKBP12-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways involved in G1 progression in several cell types, as well as in yeast. The binding of FRAP to FKBP12-rapamycin correlated with the ability of these ligands to inhibit cell cycle progression.mTOR蛋白是一种丝氨酸／苏氨酸蛋白激酶（Ser/Thr），是调节细胞生长和增殖的重要信号转导分子，在细胞的生长、分化、增殖、迁移和存活上扮演了重要的角色。由于mTOR信号通路在细胞周期进程中发挥了重要作用，细胞周期进程调节异常与许多疾病尤其是癌症的发生、发展有关，mTOR信号通路的失调可引起多种肿瘤的发生。