Anti-Frizzled 2Wnt信号受体FZD2蛋白抗体

本公司经销Frizzled 2，Wnt信号受体FZD2蛋白抗体，克隆类型为polyclonal，宿主来源是Rabbit，Frizzled 2Wnt信号受体FZD2蛋白抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-6623R
英文名称：Anti-Frizzled 2
中文名称：Wnt信号受体FZD2蛋白抗体
其他名称：名Frizzled homolog 2; Frizzled-2; Frizzled2; Fz 2; Fz-2; Fz2; FZD 2; FZD2; FZD2_HUMAN; FzE 2; FzE2; hFz 2; hFz2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 60kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, cow, dog, Rb
产品介绍：The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The mammalian homolog of frizzled as well as several secreted mammalian frizzled-related proteins （FRPs） have been described. The frizzled proteins contain seven transmembrane domains, a cysteine-rich domain in the extracellular region ａnd a carboxy terminal Ser/Thr-xxx-Val motif. They function as receptors for Wnt ａnd are generally coupled to G proteins. Expression of frizzled-2 can be observed in the fetal kidney ａnd lung ａnd in the adult ovary ａnd colon. The Wnt/cGMP/Ca2+ pathway is mediated by frizzled-2 . It binds Wnt proteins ａnd signals by activating the release of stored calcium. Expression of frizzled-2 is regulated by Angiotensin II. Activated frizzled-2 suppresses the activity of protein kinase G, ａnd activates NFAT-dependent transcription, the phosphatidylinositol pathway ａnd calcium sensitive enzymes.Function : Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin ａnd activation of Wnt target genes. A second signaling pathway involving PKC ａnd calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction ａnd intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.Subcellular Location : Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.Tissue Specificity : Widely expressed. In the adult, mainly found in heart, placenta, skeletal muscle, lung, kidney, pancreas, prostate, testis, ovary ａnd colon. In the fetus, expressed in brain, lung ａnd kidney. Low levels in fetal liver.Similarity : Belongs to the G-protein coupled receptor Fz/Smo family.Contains 1 FZ （frizzled） domain.