Anti-Nucleolin/C23核仁蛋白C23抗体

本公司经销Nucleolin/C23，核仁蛋白C23抗体，克隆类型为polyclonal，宿主来源是Rabbit，Nucleolin/C23核仁蛋白C23抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-8536R
英文名称：Anti-Nucleolin/C23
中文名称：核仁蛋白C23抗体
其他名称：名C23; NCL; Nucl; NUCL_HUMAN; Nucleolin; Protein C23.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 76kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, pig, hrs, dog
产品介绍：Nucleolin is the major nucleolar protein of growing eukaryotic cells. C23 （nucleolin, NCL） is a eukaryotic nucleolar phosphoprotein that influences synthesis ａnd maturation of ribosomes. C23 localizes to dense fibrillar regions of the nucleolus. It contains four RNA binding domains that interact with pre-rRNA during synthesis. C23 can influence RNA processing, ribosomal gene transcription ａnd nucleolar targeting of ribosomal components. It is known to associate with a variety of proteins, including the nucleolar protein B23. Phosphorylation by Cdc2 ａnd casein kinase II causes translocation of C23 from the nucleolus to the cytoplasm. Mitotic phosphorylated forms of Bcl-2 are present in nuclear structures in prophase Hela cells together with C23 ａnd Ki-67. Retinoic acid-induced apoptosis leads to C23 down-regulation ａnd Bcl-2 mRNA instability. C23 binds the human telomerase reverse transcriptase subunit （TERT） through interactions with its RNA binding domain 4 ａnd carboxyl-terminal RGG domain, ａnd this interaction is critical for the nucleolar localization of human TERT.Subcellular Location : Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.Similarity : Contains 4 RRM （RNA recognition motif） domains.