Anti-LMO4乳腺肿瘤自身抗原LMO4抗体

本公司经销LMO4，乳腺肿瘤自身抗原LMO4抗体，克隆类型为polyclonal，宿主来源是Rabbit，LMO4乳腺肿瘤自身抗原LMO4抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-5966R
英文名称：Anti-LMO4
中文名称：乳腺肿瘤自身抗原LMO4抗体
其他名称：名LMO 4; Breast tumor autoantigen; LIM domain only 4; LIM domain only protein 4; LIM domain transcription factor LMO 4; LIM domain transcription factor LMO4; LMO-4; LMO4; LMO4_HUMAN.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 18kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, chk
产品介绍：The LIM-only （LMO） proteins, LMO1 ａnd LMO2, are nuclear factors that are characterized by a conserved LIM domain （1）. The LIM domain consists of a cysteine-rich zinc-binding motif that is present in a variety of transcription factors, including the LIM homeobox （LHX） proteins expressed in the central nervous system ａnd involved in cell differentiation （2）. LMO1 ａnd LMO2 are expressed in the adult CNS in a cell type-specific manner, where they are differentially regulated by neuronal activity ａnd are involved in regulating the cellular differentiated phenotype of neurons （3）. LMO2 lacks a specific DNA-binding homeobox domain but rather assembles into transcriptional regulatory complexes to mediate gene expression by interacting with the widely expressed nuclear LIM interactor （NLI） （4）. NLI, known also as CLIM-1, ａnd the related protein CLIM-2 facilitate the formation of heteromeric LIM complexes ａnd also enhance the nuclear retention of LIM proteins （5）. LMO2 ａnd the related protein LMO4 are expressed in thymic precursor cells （6）. LMO4 is also expressed in mature T cells, cranial neural crest cells, somite, dorsal limb bud mesenchyme, motor neurons, ａnd Schwann cell progenitors （7）. Function : Probable transcriptional factor.Subunit : Interacts strongly with LDBS. Interacts with DEAF1, CLIM1 ａnd CLIM2. Interacts （via the LIM zinc-binding domain 1） with RBBP8. Interacts with BRAC1 （via the BRCT domains）; the interaction represses BRCA1 transcriptional activity.Similarity : Contains 2 LIM zinc-binding domains.