Anti-LGI4含亮氨酸神经胶质瘤失活蛋白4抗体

本公司经销LGI4，含亮氨酸神经胶质瘤失活蛋白4抗体，克隆类型为polyclonal，宿主来源是Rabbit，LGI4含亮氨酸神经胶质瘤失活蛋白4抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-8303R
英文名称：Anti-LGI4
中文名称：含亮氨酸神经胶质瘤失活蛋白4抗体
其他名称：名Leucine rich glioma inactivated gene 4;Leucine rich glioma inactivated protein 4;leucine-rich repeat LGI family member 4; Leucine rich repeat LGI family member 4;LGI1 like protein 3;LGI4;Lgi4 protein;Lgil3.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 59kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：LGI4, also known as leucine-rich glioma-inactivated protein 4, is a 537 amino acid secreted glycosylated protein that is widely expressed, with highest levels found within the nervous system. Interestingly, siRNA knockdown studies of LGI4 expression in Schwann cells have been shown to result in the inhibition of myelination, thus suggesting that LGI4 is an essential component of myelin formation ａnd axon segregation. LGI4 shares significant homology with its other family members, LGI1, LGI2 ａnd LGI3. Significantly, mutations in the gene encoding LGI1 have been linked to human temporal lobe epilepsy and, given the sequence similarity of LGI4, it is likely that it also may be implicated in the pathology of seizures. LGI4 is localized subcellularly to the Golgi, ER ａnd vesicles. There are two isoforms of LGI4 that are produced as a result of alternative splicing events.Subcellular Location : SecretedTissue Specificity : Widely expressed, with highest expression in brain.