Anti-KLK9激肽释放酶9抗体（舒血管素9）

本公司经销KLK9，激肽释放酶9抗体（舒血管素9），克隆类型为polyclonal，宿主来源是Rabbit，KLK9激肽释放酶9抗体（舒血管素9）可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1967R
英文名称：Anti-KLK9
中文名称：激肽释放酶9抗体（舒血管素9）
其他名称：名Kallikrein 9; kallikrein-like protein 3; KLK-L3; Kallikrein 8; Kallikrein 9; Kallikrein L3; Kallikrein Like 3; kallikrein related peptidase 9;Kallikrein8;Kallikrein9; KLK 8; KLK 9;KLK L3; KLK8; KLK9; KLKL 3; KLKL3.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 28kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, hrs
产品介绍：Kallikrein 9, also known as Kallikrein-Like 3 （KLK-L3）, is a chymotrypsin-like serine proteinase. Kallikrein 9 was discovered as the locus for kallikreins on chromosome 19 was more fully mapped ａnd found by similarity to the other tissue kallikreins. Kallikrein 9 has been found in the ovary, thymus, testis, prostate, skin, breast ａnd neuronal tissues ａnd is made by many cell lines in culture. Kallikrein 9 levels in breast cancer ａnd uterine cancer patients have been reported to ｄrop as the disease progresses, thus hK9 might be considered a favorable prognostic marker. Different splice variants of hK9 have been reported, although it is not yet known if they produce functional proteins. The full length Kallikrein 9 encodes for a 250 amino acid protein, with a predicted mass of 27.5 kDa ａnd a pI of 7.53. The 234 amino acid form predicts a protein of 26 kDa with a pI of 9.76 ａnd this quite basic pI might give the shorter form a very different function or localization. The shorter sequence also diverges before the catalytic serine residue, making it unlikely to be proteolytically active. Pre-pro-kallikrein 9 has the 17 amino acid signal sequence is removed before secretion, ａnd the Pro-kallikrein 9 is activated to Kallikrein 9 by removal of the 5 amino acid propeptide domain.Subcellular Location : Secreted.Tissue Specificity : Skin, thymus, trachea, cerebellum ａnd spinal cord.Similarity : Belongs to the peptidase S1 family. Kallikrein subfamily.Contains 1 peptidase S1 domain.KLK9目前认为是卵巢癌 宫颈癌 子宫内膜癌等其他肿瘤,很有意义的标志物。激肽释放酶KLK是激肽系统的主要限速酶，它是一组存在于多数组织和体液中的丝氨酸蛋白酶，是一种肽链内切酶。KLK又称血管舒缓素，包括15个家族成员。在不同的组织中广泛表达,具有蛋白水解酶的活性。它特异性的在碳末端切割底物肽，可裂解激肽原释放具有活性的激肽，由激肽发挥对心血管系统及肾脏功能的调节作用。组织KLK是一个大的基因家族，主要分布在肺、肾、血管、脑、肾上腺组织，为一种中等大小的糖蛋白。