Anti-Phospho-KSR1 (Ser392)磷酸化Ras信号转导KSR1蛋白抗体

本公司经销Phospho-KSR1 （Ser392），磷酸化Ras信号转导KSR1蛋白抗体，克隆类型为polyclonal，宿主来源是Rabbit，Phospho-KSR1 （Ser392）磷酸化Ras信号转导KSR1蛋白抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-3240R
英文名称：Anti-Phospho-KSR1 （Ser392）
中文名称：磷酸化Ras信号转导KSR1蛋白抗体
其他名称：名BKSR 1; BKSR1; dKsr; EK 31; EK31; hb; Kinase suppressor of ras 1; Kinase suppressor of ras; KSR 1; KSR1; Positive Ras signaling mediator family member; RSU 2; RSU2; SR 31; SR31; Suppressor of activated let 60 Ras SUR3; Suppressor of Ras1 31.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 102kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：KSR1 is a molecular scaffold ａnd positive regulator of the Raf/MEK/ERK phosphorylation cascade. It was initially considered to be a protein kinase acting in the Ras pathway. KSR1 is required for maximal ERK activation induced by growth factors ａnd by some cytotoxic agents. In resting cells, phosphorylated KSR1 is cytoplasmic ａnd in stimulated cells, dephosphorylated KSR1 is membrane associated.Function : Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK ａnd RAF phosphorylation ａnd activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.Subunit : Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.Contains 1 phorbol-ester/DAG-type zinc finger.Contains 1 protein kinase domain.Subcellular Location : Cytoplasm. Membrane. In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, ａnd it moves from the cytoplasm to the cell periphery.Post-translational modifications : Phosphorylated on Ser-309 and, to a higher extent, on Ser-404 by MARK3. Dephosphorylated on Ser-404 by PPP2CA. In resting cells, phosphorylated KSR1 is cytoplasmic ａnd in stimulated cells, dephosphorylated KSR1 is membrane-associated （By similarity）.Similarity : Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.Contains 1 phorbol-ester/DAG-type zinc finger.Contains 1 protein kinase domain.