谷氨酸脱羧酶-67抗体,Anti-GAD67抗体

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产品名称  谷氨酸脱羧酶-67抗体,Anti-GAD67抗体                                             
产品编号 BYk-0325R    

相关标记 HRP Biotin Gold RBITC AP FITC Cy3 Cy5 Cy5.5 Cy7 PE PE-Cy3 PE-Cy5 PE-Cy5.5
PE-CY7 APC Alexa Fluor 350 Alexa Fluor 488 Alexa Fluor 555 Alexa Fluor 647
浓 度 1mg/1ml
抗体来源 Rabbit OR MOUSE
克隆类型 polyclonal or monoclonal
产品类型 一抗
产品用途  科研实验，用于免疫组化实验，WB实验、IF、IP、ELISA实验，相应的标记抗体有HRP标记抗体，FITC标记，BIO等。
性 状 Lyophilized or Liquid
亚 型 IgG     

谷氨酸脱羧酶-67抗体,Anti-GAD67抗体保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

谷氨酸脱羧酶-67抗体,Anti-GAD67抗体产品说明：

Glutamic Acid Decarboxylase （GAD） catalyzes the conversion of L glutamate to g-aminobutyric acid （GABA）, the principal inhibitory neurotransmitter in the brain, ａnd a putative paracrine signal molecule in pancreatic islets. GAD has a restricted tissue distribution. It is highly expressed in the cytoplasm of GABAergic neurons in the central nervous system （CNS） ａnd pancreatic beta cells. It is also present in other non-neuronal tissues such as testis, oviduct ａnd ovary. GAD is also transiently expressed in non-GABAergic cells of the embryonic ａnd adult nervous system, suggesting its involvement in development ａnd plasticity.
GAD exists as two isoforms, GAD65 ａnd GAD67 （molecular masses of 65 ａnd 67 kD, respectively） that are encoded by two different genes. GAD65 is an ampiphilic, membraneanchored protein, （585 amino acid residues） ａnd is encoded on human chromosome 10. GAD67 is a cytoplasmic protein （594 amino acid residues） ａnd is encoded on chromosome 2. There is 64% amino acid identity between the two isoforms, with the highest diversity located at the N terminus, which in GAD65 is required for targeting the enzyme to GABA-containing secretory vesicles. The two isoforms appear to have distinct intraneuronal distribution in the brain. GAD65 has been identified as an autoantigen in insulindependent diabetes mellitus （IDDM） ａnd stiff-man syndrome （SMS）, IDDM is an autoimmune disease that results from T cell mediated destruction of pancreatic insulin-secreting beta cells. Islet-reactive T cells ａnd antibodies primarily to GAD65 （also named beta cell autoantigen） can be detected in peripheral blood of 80% of recent-onset IDD patients ａnd in pre-diabetic high-risk subjects before onset of clinical symptoms. This suggests that GAD may be an important marker in the early stages of the disease. Also, autoantibodies to GAD65 ａnd GAD67 are detected in animal models of IDDM, including the non-obese diabetes （NOD） mouse. In the NOD mouse, T cell reactivity is initially restricted to the C terminal regions of GAD65, but later spreads to other parts of GAD65. Stiff-man syndrome （SMS）, a rare disorder of the CNS, is characterized by progressive rigidity of the body musculature with painful spasms, due to impairment of the GABAergic neurotransmission.