Phospho-IRF3 (Ser396)磷酸化干扰素调节因子3

本公司经销Phospho-IRF3 （Ser396），磷酸化干扰素调节因子3，克隆类型为polyclonal，宿主来源是Rabbit，Phospho-IRF3 （Ser396）磷酸化干扰素调节因子3可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-3195R
英文名称：Anti-Phospho-IRF3 （Ser396）
中文名称：磷酸化干扰素调节因子3
其他名称：名Interferon regulatory factor 3; IRF-3; IRF 3.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 44-47kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：This protein is a member of the interferon regulatory transcription factor （IRF） family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus ａnd activates the transcription of interferons alpha ａnd beta, as well as other interferon-induced genes.Subunit : Homodimer; phosphorylation-induced. Interacts with CREBBP. May interact with MAVS. Interacts with IKBKE ａnd TBK1. Interacts with TICAM1 ａnd TICAM2. Interacts with rotavirus A NSP1 （via C-terminus）; this interaction leads to the proteasome-dependent degradation of IRF3. Interacts with RBCK1. Interacts with TRIM21. Interacts with HERC5.Subcellular Location : Cytoplasm. Nucleus. Note=Shuttles between cytoplasmic ａnd nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm.Tissue Specificity : Expressed constitutively in a variety of tissues.Similarity : Belongs to the IRF family. Contains 1 IRF tryptophan pentad repeat DNA-binding domain.干扰素调节因子家族是一大类对干扰素起调控作用的转录因子的统称。 一般认为干扰素调节因子（IRF）通过调节干扰素的表达而行使其抗病毒、应激、免疫调节功能。近年来，研究人员发现IRF在细胞凋亡、细胞周期、细胞分化、肿瘤发生中也起着重要的调节作用。