SDF-1/CXCL12基质细胞衍生因子－1抗体

本公司经销SDF-1/CXCL12，基质细胞衍生因子－1抗体，克隆类型为polyclonal，宿主来源是Rabbit，SDF-1/CXCL12基质细胞衍生因子－1抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0783R
英文名称：Anti-SDF-1/CXCL12
中文名称：基质细胞衍生因子－1抗体
其他名称：名SDF1 alpha; C-X-C motif chemokine 12; Chemokine （C X C motif） ligand 12;CXCL12; hIRH; hSDF-1; Intercrine reduced in hepatomas; IRH; PBSF;PBSF; Pre B cell growth stimulating factor; Pre-B cell growth-stimulating factor; SCYB12; SDF 1 alpha; SDF 1; SDF 1 beta; SDF 1b; SDF-1; SDF-1-alpha（3-67）; SDF1; SDF1_HUMAN; SDF1a; SDF1b; Stromal cell derived factor 1; TLSF a; TLSF b; TLSFa; TLSFb; TPAR1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 8kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo, dog, chk
产品介绍：The cell source growth factor 1: tend to turn the factor CXCL12 to have tend of mightiness to the lymphoid cell to turn the function ａnd rise the important function in the growth.The CXCL12 leading builds the blood stem cell in embryo develop from embryo＇s liver to the change residence of marrow. CXCL12 can expression in many tissues （ include the brain, thymus gland, heart, lung, liver, kidney, marrow, spleen）. Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors ａnd interferons involved in mitogenic, chemotactic, ａnd inflammatory activity; many members contain an RCxC motif which may be a general requirement for binding to CXC chemokine receptors; those with the ELR motif are chemotatic for neutrophils ａnd have been shown to be angiogenic, while those without the motif act on T ａnd B cells, ａnd are typically angiostatic; exist as monomers ａnd dimers, but are believed to be functional as monomers; found only in vertebrates ａnd a few viruses.Function : Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid ａnd transient rise in the level of intracellular calcium ions ａnd chemotaxis. Also binds to another C-X-C chemokine receptor CXCR7, which activates the beta-arrestin pathway ａnd acts as a scavenger receptor for SDF-1. SDF-1-beta（3-72） ａnd SDF-1-alpha（3-67） show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha（3-67） ａnd thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration ａnd a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes ａnd T-lymphocytes through its receptors, CXCR4 ａnd CXCR7, ａnd decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation ａnd internalization of CXCR7 expressed in various cells.Subunit : Monomer or homodimer; in equilibrium. Dimer formation is induced by non acidic pH ａnd the presence of multivalent anions, ａnd by binding to CXCR4 or heparin. Monomeric form is required for full chemotactic activity ａnd resistance to ischemia/reperfusion injury, whereas the dimeric form acts as a partial agonist of CXCR4, stimulating Ca2+ mobilization but with no chemotactic activity ａnd instead acts as a selective antagonist that blocks chemotaxis induced by the monomeric form. Interacts with the N-terminus of CXCR7.Subcellular Location : Secreted.Tissue Specificity : Isoform Alpha ａnd isoform Beta are ubiquitously expressed, with highest levels detected in liver, pancreas ａnd spleen. Isoform Gamma is mainly expressed in heart, with weak expression detected in several other tissues. Isoform Delta, isoform Epsilon ａnd isoform Theta have highest expression levels in pancreas, with lower levels detected in heart, kidney, liver ａnd spleen.Post-translational modifications : Processed forms SDF-1-beta（3-72） ａnd SDF-1-alpha（3-67） are produced after secretion by proteolytic cleavage of isoforms Beta ａnd Alpha, respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha（1-67） intermediate before being processed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans.Similarity : Belongs to the intercrine alpha （chemokine CxC） family.基质细胞衍生因子－1（SDF-1）又称趋化因子CXCL12 是小分子的细胞因子，属于趋化因子蛋白家族。它有两种形式, SDF-1α/CXCL12a和SDF-1β/CXCL12b。趋化因子有四个保守的半胱氨酸残基形成两对双硫键以构成趋化因子的特殊结构。第二半胱氨酸残基之间隔着一个介入氨基酸残基。基质细胞源性生长因子1:趋化因子CXCL12对淋巴细胞有强烈的趋化作用并在发育中起重要作用。在胚胎发育中CXCL12引导造血干细胞从胎儿肝脏到的迁徙。 CXCL12可以在许多组织（包括脑,胸腺,心,肺,肝,肾,,）中表达。趋化因子CXCL12的受体是CXCR4。但是,Z近有人认为CXCL12还可以与CXCR7受体结合。