本公司经销SASS6,纺锤体组装异常蛋白6抗体,克隆类型为polyclonal,宿主来源是Rabbit,SASS6纺锤体组装异常蛋白6抗体可应用于WB、elisa、IP、IF、IHC等实验,欢迎垂询订购!
本公司经销SASS6,纺锤体组装异常蛋白6抗体,克隆类型为polyclonal,宿主来源是Rabbit,SASS6纺锤体组装异常蛋白6抗体可应用于WB、elisa、IP、IF、IHC等实验,欢迎垂询订购!
货号:BY-9301R
英文名称:Anti-SASS6
中文名称:纺锤体组装异常蛋白6抗体
其他名称:名HsSAS 6;HsSAS6;MGC119440;SAS 6;SAS6;SASS 6;Spindle assembly 6 homolog (C. elegans);Spindle assembly 6 homolog;Spindle assembly abnormal protein 6 homolog.
抗体来源:Rabbit
克隆类型:polyclonal
蛋白分子量:predicted molecular weight: 74kDa
纯化方法:affinity purified by Protein A
交叉反应:hu, mo, rat
产品介绍:SAS-6 (spindle assembly abnormal protein 6 homolog, HsSAS-6) is a 657 amino acid protein encoded by the human gene SAS6. SAS-6 is a component of the centrosome that contains one PISA (present in SAS-6) domain. LK4, SAS-6, CPAP and other centriole related proteins are required at different stages of procentriole formation and were associated with different centriolar structures. SAS-6 associates only transiently with nascent procentrioles, whereas CEP135 and CPAP form a core structure within the proximal lumen of both parental and nascent centrioles. SAS-6 is necessary for procentriole formation in human cell lines and is localized asymmetrically next to the centriole at the onset of procentriole formation. SAS-6 levels oscillate during the cell cycle; it is degraded in mitosis starting at anaphase, and it accumulates again at the end of the following G1 phase. The anaphase-promoting complex targets SAS-6 for degradation by the 26S Proteasome, and a KEN box in the C-terminus of SAS-6 is necessary for its degradation. Increased SAS-6 levels promoted the formation of multiple procentrioles forming next to a single centriole.Subcellular Location : Cytoplasm; cytoskeleton; centrosome. Cytoplasm; cytoskeleton; centrosome; centriole. Note: Component of the centrosome. Associated only transiently with nascent procentrioles during centriole biogenesis.