Sg V/Secretogranin V神经内分泌颗粒蛋白5抗体

本公司经销Sg V/Secretogranin V，神经内分泌颗粒蛋白5抗体，克隆类型为polyclonal，宿主来源是Rabbit，Sg V/Secretogranin V神经内分泌颗粒蛋白5抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-11425R
英文名称：Anti-Sg V/Secretogranin V
中文名称：神经内分泌颗粒蛋白5抗体
其他名称：名7B2;7B2 protein;APPG;Neuroendocrine protein 7B2;P7B2;Pituitary polypeptide;Pituitary polypeptide;Prohormone convertase chaperone;SCG 5;SCG5;Secretogranin 5;Secretogranin V 7B2 protein;Secretogranin5;SecretograninV;Secretory granule endocrine protein I;Secretory granule endocrine protein I;Secretory granule neuroendocrine protein 1 7B2 protein;Secretory granule neuroendocrine protein 1;Sg V;SGNE 1;SGNE1;SgV.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 25kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, chi, pig
产品介绍：Sg V is a 212 amino acid protein that is secreted by endocrine ａnd neuroendocrine secretory granules ａnd belongs to the 7B2 family. Existing as two alternatively spliced isoforms, Sg V interacts with PC2 and, via this interaction, functions as a molecular chaperone for PC2, effectively preventing its premature activation in regulated secretory pathways. More specifically, Sg V binds to PC2 ａnd facilitates its transport from the endoplasmic reticulum to secretory compartments, thus allowing PC2 to be cleaved ａnd activated during the correct phase of the regulated secretory pathway. Sg V is subject to post-translational sulfation on specific tyrosine residues ａnd is underexpressed in medulloblastomas, suggesting a role in tumor suppression. The gene encoding Sg V maps to human chromosome 15, which houses over 700 genes ａnd comprises nearly 3% of the human genome.Function : Secretogranin V may have intracellular functions other than PC2 maturation in certain cells, although some recent work shows a discordancy between mRNA expression ａnd enzymic activity. The mechanism for PC2 maturation appears to involve pro-Secretogranin V binding to inactive pro-PC2 via its polyproline motif （116 PPNPCP 121） in the endoplasmic reticulum ａnd chaperoning pro-PC2 to a later secretory pathway compartment where maturation of PC2 proceeds once pro-Secretogranin V is proteolytically processed by a furin-like convertase into a 21kDa fragment ａnd a C-terminal peptide. It is the C-terminal peptide that potently inhibits maturation of pro-PC2 until the complex is subjected to a decreasing pH gradient along the secretory pathway. It seems likely that mature PC2 then cleaves the CT peptide at its internal lys-lys site. Secretogranin V knockout mice develop a severe Cushings-like phenotype ａnd exhibit multiple metabolic ａnd hormonal abnormalities, indicating that Secretogranin V is required for activation of PC2 in vivo. Conversely, PC2-null mice appear to be viable.Subcellular Location : Neuroendocrine ａnd endocrine secretory granules.