SPON2/M spondin/Mindin细胞外基质底物反应蛋白2抗体

本公司经销SPON2/M spondin/Mindin，细胞外基质底物反应蛋白2抗体，克隆类型为polyclonal，宿主来源是Rabbit，SPON2/M spondin/Mindin细胞外基质底物反应蛋白2抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-11064R
英文名称：Anti-SPON2/M spondin/Mindin
中文名称：细胞外基质底物反应蛋白2抗体
其他名称：名SPON 2;Differentially expressed in cancerous ａnd non-cancerous lung cells 1;DIL 1;DIL-1;DIL1;M spondin;Mindin;Spon2;SPON2_HUMAN;Spondin 2;Spondin-2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 36kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：The Thrombospondin proteins, Thrombospondins 1-4 ａnd Thrombospondin 5 （also designated COMP）, compose a family of glycoproteins that are involved in cell-to-cell ａnd cell-to-matrix signaling. These extracellular, cell-surface proteins form complexes of both homo- ａnd heteromultimers. Spondin-2, or Mindin, is also designated DIL-1 for its differential expression in cancerous ａnd non-cancerous lung cells. Full-length SPON2 cDNA encodes a 331 amino acid protein with a domain arrangement similar to zebrafish F-Spondin ａnd Mindin-1/Mindin-2: an FS1 domain, an FS2 domain, a hydrophobic signal sequence in the N-terminus ａnd a Thrombospondin type I repeat. Immunoblot analysis demonstrates expression of dimers ａnd oligomers in a concentration-dependent manner under nonreducing conditions.Function : Cell adhesion protein that promotes adhesion ａnd outgrowth of hippocampal embryonic neurons. Binds directly to bacteria ａnd their components ａnd functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response ａnd represents a unique pattern-recognition molecule in the ECM for microbial pathogens （By similarity）. Binds bacterial lipopolysaccharide （LPS）.Subcellular Location : Secreted > extracellular space > extracellular matrix.Tissue Specificity : Expressed in normal lung tissue but not in lung carcinoma cell lines.Similarity : Contains 1 spondin domain.Contains 1 TSP type-1 domain.