VHL/HRCA1脑视网膜血管瘤G7蛋白抗体（逢希伯-林道氏病）

本公司经销VHL/HRCA1，脑视网膜血管瘤G7蛋白抗体（逢希伯-林道氏病），克隆类型为polyclonal，宿主来源是Rabbit，VHL/HRCA1脑视网膜血管瘤G7蛋白抗体（逢希伯-林道氏病）可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1367R
英文名称：Anti-VHL/HRCA1
中文名称：脑视网膜血管瘤G7蛋白抗体（逢希伯-林道氏病）
其他名称：名Von Hippel Lindau;von Hippel-Lindau syndrome protein homolog; Hippel-Lindau disease tumor suppressor VHL; von Hippel-Lindau tumor suppressor isoform 1; VHL; HRCA1; RCA1; VHL1; von Hippel-Lindau disease tumor suppressor isoform 2;pVHL;pVHL;G7 protein;Elongin binding protein;Protein G7;VHL 1;VHL_HUMAN;VHL1;VHLH;Von Hippel Lindau disease tumor suppressor;von Hippel Lindau syndrome;von Hippel Lindau tumor suppressor;Von Hippel-Lindau disease tumor suppressor.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 20/23kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, cow
产品介绍：Von Hippel-Lindau syndrome （VHL） is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant ａnd benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, ａnd cullin-2, ａnd possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination ａnd degradation of hypoxia-inducible-factor （HIF）, which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq].von Hippel-Lindau是一种肿瘤YZ因子，在细胞对氧的感受过程中发挥关键作用，VHL蛋白除了调节血管生成外还在调节细胞的生长和生存、对调节细胞周期、细胞凋亡和细胞外基质方面起重要作用。