UCHL1/PGP9.5神经细胞胞浆蛋白9.5抗体（蛋白基因产物9.5）

本公司经销UCHL1/PGP9.5，神经细胞胞浆蛋白9.5抗体（蛋白基因产物9.5），克隆类型为polyclonal，宿主来源是Rabbit，UCHL1/PGP9.5神经细胞胞浆蛋白9.5抗体（蛋白基因产物9.5）可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-3806R
英文名称：Anti-UCHL1/PGP9.5
中文名称：神经细胞胞浆蛋白9.5抗体（蛋白基因产物9.5）
其他名称：名Gracile axonal dystrophy; Neuron cytoplasmic protein 9.5; Park 5; Park5; Parkinson Disease 5; PGP 9.5; PGP9.5; PGP95; Protein gene product 9.5; Ubiquitin C terminal esterase L1; Ubiquitin C terminal hydrolase （neuron specific）; Ubiquitin C terminal hydrolase; Ubiquitin carboxyl terminal esterase L1; Ubiquitin carboxyl terminal hydrolase isozyme L1; Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin thioesterase L1; Ubiquitin thiolesterase; Ubiquitin thiolesterase L1; UCH L1; UCH-L1; UCHL1; UCHL1_HUMAN.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 25kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, pig, hrs, Gpig
产品介绍：catalyzes the hydrolysis of ubiquitin carboxy-terminal thiolesters to form ubiquitin ａnd a thiol; may play a role in neuropathic pain [RGD].Found in neuronal cell bodies ａnd processes throughout the neocortex （at protein level）. Expressed in neurons ａnd cells of the diffuse neuroendocrine system ａnd their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease ａnd Alzheimer disease patients.Function : Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors ａnd of ubiquitinated proteins. This enzyme is a thiol protease that recognizes ａnd hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin ａnd may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.Subcellular Location : Cytoplasm. Endoplasmic reticulum membrane. About 30% of total UCHL1 is associated with membranes in brain.Tissue Specificity : Found in neuronal cell bodies ａnd processes throughout the neocortex （at protein level）. Expressed in neurons ａnd cells of the diffuse neuroendocrine system ａnd their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease ａnd Alzheimer disease patients.Post-translational modifications : O-glycosylated.DISEASE : Defects in UCHL1 are the cause of Parkinson disease type 5 （PARK5） [MIM:613643]; also known as Parkinson disease autosomal dominant 5. PARK5 is a complex neurodegenerative disorder with manifestations ranging from typical Parkinson disease to dementia with Lewy bodies. Clinical features include parkinsonian symptoms （resting tremor, rigidity, postural instability ａnd bradykinesia）, dementia, diffuse Lewy body pathology, autonomic dysfunction, hallucinations ａnd paranoia.Similarity : Belongs to the peptidase C12 family.该抗原是一种神经特异性蛋白，广泛分布于与外周神经系统的神经元和神经纤维、神经内分泌细胞、肾小管段、睾丸精原细胞、Leydig细胞、卵细胞以及妊娠与非妊娠黄体内的某些细胞。用于标记神经元，对研究几种人慢性神经变性性疾病中广泛存在的细胞包涵体特征较有意义。