本公司经销TRPM8，“冷”蛋白TRPM8抗体，克隆类型为polyclonal，宿主来源是Rabbit，TRPM8“冷”蛋白TRPM8抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！
本公司经销TRPM8，“冷”蛋白TRPM8抗体，克隆类型为polyclonal，宿主来源是Rabbit，TRPM8“冷”蛋白TRPM8抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！
货号：BY-9045R
英文名称：Anti-TRPM8
中文名称：“冷”蛋白TRPM8抗体
其他名称：名LTrpC-6;LTrpC6 antibodyShort form of the TRPM8 cationic channel;Transient receptor potential cation channel subfamily M member 8;Transient receptor potential p8;Trp p8;Trp-p8;Trpm8;TRPM8_HUMAN;TRPP8;MGC2849;transient receptor potential-p8;Long transient receptor potential channel 6.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 128kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold ａnd modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, ａnd cesium ａnd divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening ａnd closing.Subcellular Location : MembraneTissue Specificity : Expressed in prostate. Also expressed in most in prostate tumors. Also expressed in non-prostatic primary tumors such as colon, lung, breast ａnd skin tumors.TRPM8与感应热和辣的蛋白质属于同一家族，它存在于特定神经细胞的细胞膜上，成为响应外界信号的开关通道。科学家研究发现，当温度低于27摄氏度或者醇存在的条件下，TRPM8通道都会打开，使钙离子等带正电的粒子进入细胞。TRPM8的蛋白质在产生冷知觉的过程中起着主导作用，并且控制着低温对机体疼痛的缓解效果,TRPM8故称是“冷”蛋白。
