phospho-TERT(Ser1125)磷酸化端粒酶逆转录酶抗体

本公司经销phospho-TERT（Ser1125），磷酸化端粒酶逆转录酶抗体，克隆类型为polyclonal，宿主来源是Rabbit，phospho-TERT（Ser1125）磷酸化端粒酶逆转录酶抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-5605R
英文名称：Anti-phospho-TERT（Ser1125）
中文名称：磷酸化端粒酶逆转录酶抗体
其他名称：名p-TERT（Ser1125）; TERT（phospho S1125）; EST2; hEST2; TCS1; Telomerase associated protein 2; Telomerase Catalytic Subunit; Telomere Reverse Transcriptase; TERT; TP2; TRT.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 124kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Telomerase are large DNA-protein complexes with telomerase expression being the subject of recent research due to its link to cell immortalization. Recent evidence has shown that MYC upregulates the catalytic subunit of telomerase, TERT, ａnd that TERT cooperates with HPV E7 in cell immortalization. Ever since the discovery that telomeres are short in cancer cells ａnd telomerase is activated in immortal cells, telomerase has been associated with oncogenes. During the past year, major advances have been made in understanding the link between telomerase expression ａnd cell immortality. Studies of yeast telomeres have revealed an unexpected role for the non-homologous end-joining machinery in telomere maintenance ａnd have provided the first definitive evidence that telomeres play a critical role in meiosis. Identification of new telomere proteins has led to a better understanding of vertebrate telomere structure ａnd function.端粒酶逆转录酶hTERT是构成端粒酶的组分之一,是端粒酶活性的必需和限速成分,其水平决定细胞端粒酶的活性.YZhTERT可降低端粒酶的活性,从而YZ瘤细胞生长.目前对hTERT的研究已成为端粒酶研究的热点问题,已发现TERT蛋白表达在肿瘤诊断中有重要意义,并制备了hTERT抗体及应用核酶技术等来YZhTERT蛋白的表达,YZ端粒酶活性,从而YZ肿瘤的生长.端粒反转录酶又称端粒酶催化亚单位 （hTRT；Telomerase catalytic subunit；HEST2；Telomerase-associated protein 2；TP2；Telomerase reverse transcriptase；telomerase catalytic subunit）是细胞永生化及恶性肿瘤发生过程中的端粒酶活化的主要限速步骤。hTRT基因表达可以反映端粒酶活性，与端粒酶活性具有平行关系.