Nucleoprotein TPR核蛋白易位启动子区域TPR抗体

本公司经销Nucleoprotein TPR，核蛋白易位启动子区域TPR抗体，克隆类型为polyclonal，宿主来源是Rabbit，Nucleoprotein TPR核蛋白易位启动子区域TPR抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-5755R
英文名称：Anti-Nucleoprotein TPR
中文名称：核蛋白易位启动子区域TPR抗体
其他名称：名Nucleoprotein TPR; tpr; TPR_HUMAN; translocated promoter region （to activated MET oncogene）.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 260kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, hrs, dog, cow, pig, Rb
产品介绍：Component of the cytoplasmic fibrils of the nuclear pore complex implicated in nuclear protein import. Its N-terminus is involved in activation of oncogenic kinases. Plays a role in the mitotic spindle checkpoint.Function : Component of the cytoplasmic fibrils of the nuclear pore complex implicated in nuclear protein import. Its N-terminus is involved in activation of oncogenic kinases. Plays a role in the mitotic spindle checkpoint.Subunit : Interacts with MAD1L1 ａnd MAD2L1.Subcellular Location : Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Chromosome, centromere, kinetochore. Note=The assembly of the NPC is a stepwise process in which Trp-containing peripheral structures assemble after other components, including p62. Detected at kinetochores during prometaphase.Tissue Specificity : Highest in testis, lung, thymus, spleen ａnd brain, lower levels in heart, liver ａnd kidney.Post-translational modifications : Phosphorylated upon DNA damage, probably by ATM or ATR.DISEASE : Defects in TPR are a cause of thyroid papillary carcinoma （TPC） [MIM:188550]. TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=Chromosomal aberrations involving TPR are found in thyroid papillary carcinomas. Intrachromosomal rearrangement that links the 5＇-end of the TPR gene to the protein kinase domain of NTRK1 forms the fusion protein TRK-T1. TRK-T1 is a 55 kDa protein reacting with antibodies against the carboxy terminus of the NTRK1 protein.Involved in tumorigenic rearrangements with the MET or RAF genes.Involvement in disease;Defects in TPR are a cause of thyroid papillary carcinoma （TPC）. TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=Chromosomal aberrations involving TPR are found in thyroid papillary carcinomas. Intrachromosomal rearrangement that links the 5＇-end of the TPR gene to the protein kinase domain of NTRK1 forms the fusion protein TRK-T1. TRK-T1 is a 55 kDa protein reacting with antibodies against the carboxy terminus of the NTRK1 protein.Note=Involved in tumorigenic rearrangements with the MET or RAF genes.