RSPO1分泌性蛋白RSPO1抗体

本公司经销RSPO1，分泌性蛋白RSPO1抗体，克隆类型为polyclonal，宿主来源是Rabbit，RSPO1分泌性蛋白RSPO1抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-6185R
英文名称：Anti-RSPO1
中文名称：分泌性蛋白RSPO1抗体
其他名称：名R-Spondin; CRISTIN3; hRspo1; R spondin homolog （Xenopus laevis）; R spondin homolog; R spondin1; R-spondin-1; Roof plate specific spondin; Roof plate-specific spondin-1; RSPO; Rspo1; RSPO1_HUMAN.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 27kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb
产品介绍：Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, ａnd in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 ａnd LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.Subunit : Interacts with the extracellular domain of FZD8 ａnd LRP6. It however does not form a ternary complex with FZD8 ａnd LRP6. Interacts with WNT1. Binds heparin （By similarity）.Subcellular Location : Secreted.Tissue Specificity : Abundantly expressed in adrenal glands, ovary, testis, thyroid ａnd trachea but not in bone marrow, spinal cord, stomach, leukocytes colon, small intestine, prostate, thymus ａnd spleen.Similarity : Belongs to the R-spondin family.Contains 2 FU （furin-like） repeats.Contains 1 TSP type-1 domain.R-spondin（Rspo）是近年来新发现的蛋白家族,包括4个成员（Rspo1～4）。Rspo蛋白家族所有成员均为分泌性蛋白,均有两个富含半胱氨酸的furin-like结构域、1个TSP1结构域和富含碱性氨基酸的C端区域。Rspos通过激活并协同Wnt/β-catenin信号通路参与对细胞增殖和分化的调控,影响骨骼、肌肉、血管等组织的发育以及肢体和性腺的形成,并在多种疾病的发生过程中起重要作用。