Rb/P105 RB成视网膜细胞瘤基因抗体

本公司经销Rb/P105 RB，成视网膜细胞瘤基因抗体，克隆类型为polyclonal，宿主来源是Rabbit，Rb/P105 RB成视网膜细胞瘤基因抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-2777R
英文名称：Anti-Rb/P105 RB
中文名称：成视网膜细胞瘤基因抗体
其他名称：名OSRC; P105 RB; P105RB; PP105; PP110; pRb; RB 1; RB1; RB1 protein; Retinoblastoma 1 （including osteosarcoma）; Retinoblastoma 1; Retinoblastoma associated protein; Retinoblastoma related osteosarcoma; Retinoblastoma susceptibility gene.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 106kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, Rb, pig, hrs
产品介绍：Nuclear MarkerThe protein encoded by this gene is a negative regulator of the cell cycle ａnd was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma （RB）, bladder cancer, ａnd osteogenic sarcoma.Rb is a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors including E2F1, PU1, ATF2, UBF, Elf1 ａnd cAbl. This ability of Rb to alter transcription is regulated by phosphorylation catalyzed by the cyclin dependent protein kinases （cdks）. Rb is phosphorylated on serine ａnd threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, ａnd human papilloma virus 16E. Rb protein may act by regulating transcription ａnd loss of its function leads to uncontrolled cell growth. Aberrations in the Rb gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, ａnd leukemia.