Ryanodine Receptor心肌兰尼碱受体抗体（脑肌兰尼碱受体）

本公司经销Ryanodine Receptor，心肌兰尼碱受体抗体（脑肌兰尼碱受体），克隆类型为polyclonal，宿主来源是Rabbit，Ryanodine Receptor心肌兰尼碱受体抗体（脑肌兰尼碱受体）可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-6305R
英文名称：Anti-Ryanodine Receptor
中文名称：心肌兰尼碱受体抗体（脑肌兰尼碱受体）
其他名称：名Arrhythmogenic right ventricular dysplasia 2; ARVC 2; ARVC2; ARVD 2; ARVD2; Brain ryanodine receptor calcium release channel; Brain type ryanodine receptor; Cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor calcium release channel; Cardiac muscle type ryanodine receptor; CCO; Central core disease of muscle; HBRR; hRYR 2; hRYR2; MHS; MHS1; Ryanodine receptor 1 （skeletal）; Ryanodine receptor 1; Ryanodine receptor 2 （cardiac）; Ryanodine receptor 2; Ryanodine receptor 3; Ryanodine receptor type1; RYDR; RYR 1; RYR 2; RYR 3; RYR; RYR1; RYR2; RYR3; Sarcoplasmic reticulum calcium release channel; Skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; Skeletal muscle type ryanodine receptor; SKRR; Type 1 like ryanodine receptor; VTSIP.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 565kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, Rb, cow, pig
产品介绍：The Ryanodine Receptor （RyR） is the channel responsible for calcium release from muscle cell Sarcoplasmic Reticulum （SR） ａnd also plays a role in calcium regulation in non-muscle cells. The RyR exists as a homotetramer ａnd is predicted to have a short cytoplasmic C-terminus ａnd 4-10 transmembrane domains. The remainder of the protein, termed the "foot" region, is located in the cytoplasm between the transverse tubule ａnd the SR. Mammalian RyR isoforms are the product of three different genes: RyR-1 is expressed predominantly in skeletal muscle ａnd areas of the brain; RyR-2 is expressed predominantly in heart muscle but also found in the stomach, endothelial cells ａnd diffuse areas of the brain; ａnd RyR-3 is found in smooth muscle ａnd the brain （striatum, thalamus ａnd hippocampus）. In non-mammalian vertebrates, the RyR isoforms are termed alpha, beta ａnd cardiac which correlate loosely to the mammalian RyR-1, RyR-3 ａnd RyR-2 isoforms respectively.Subunit : Homotetramer. Heterotetramer with RYR2. Interacts with CALM. Interacts with FKBP1A.Subcellular Location : Sarcoplasmic reticulum membrane; Multi-pass membrane protein （Probable）. Membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.Tissue Specificity : Brain, skeletal muscle, placenta ａnd possibly liver ａnd kidney. In brain, highest levels are found in the cerebellum, hippocampus, caudate nucleus ａnd amygdala, with lower levels in the corpus callosum, substantia nigra ａnd thalamus.Similarity : Belongs to the ryanodine receptor （TC 1.A.3.1） family. RYR3 subfamily.Contains 3 B30.2/SPRY domains.Contains 5 MIR domains.Defects in the RYR2 gene are the cause of several heart diseases: 1） familial arrhythmogenic right ventricular dysplasia 2 （ARVD2）, also known as arrhythmogenic right ventricular cardiomyopathy 2 （ARVC2）, 2） an autosomal dominant form of stress-induced polymorphic ventricular tachycardia （VTSIP）, also known as catecholaminergic polymorphic ventricular tachycardia （CPVT） ａnd 3） familial polymorphic ventricular tachycardia （FPVT）. Ryanodine Receptor 2 contains several phosphorylatable sites. Specifically, Ser-2030 ａnd Ser-2809 （or at Ser-2808 depending on the species） can be phosphoryated by protein kinase A （PKA） ａnd Ser-2815 （or at Ser-2814 depending on the species） can be phosphorylated by CaMKII （Ca2+/calmodulin-dependent protein kinase II）.