NET1去甲肾上腺素转运蛋白/神经递质去甲肾上腺素转运体抗体

本公司经销NET1，去甲肾上腺素转运蛋白/神经递质去甲肾上腺素转运体抗体，克隆类型为polyclonal，宿主来源是Rabbit，NET1去甲肾上腺素转运蛋白/神经递质去甲肾上腺素转运体抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-6331R
英文名称：Anti-NET1
中文名称：去甲肾上腺素转运蛋白/神经递质去甲肾上腺素转运体抗体
其他名称：名NAT1; NET; NET; NET1; Norepinephrine transporter; SLC6A2; SLC6A5; SLC6A5; Sodium dependent noradrenaline transporter; Solute carrier family 6 （neurotransmitter transporter norepinephrine） member 5; Solute carrier family 6 member 2; Solute carrier family 6 member 2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 65kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, hrs, dog, cow, chk
产品介绍：Catecholamine, a term used for the hormone adrenaline ａnd its sequentially hydroxylated form noradrenaline, is involved in fight or flight responses. Noradrenaline is released from the post ganglionic sympathetic nerve endings ａnd exerts its effects locally in the immediate vicinity of its release. In the CNS, noradrenaline is involved in a number of physiological responses including mood, sleep regulation, alertness ａnd arousal, both cognitive ａnd non-cognitive expression of behaviors, ａnd control of the endocrine ａnd autonomic nervous systems. Peripherally, noradrenaline is present in sympathetic nerve endings ａnd has full control of the sympathetic nervous system. Noradrenaline released from pre-synaptic nerve terminals is reabsorbed （70-90%） by noradrenaline transporters ａnd its biological effects are terminated. The noradrenaline transport via noradrenaline transporters is an active, Na+/Cl- dependent transport process mediated by noradrenaline transporters. Noradrenaline transporters constitute the primary mechanism for inactivation of synaptically released noradrenaline, are targets for multiple antidepressants ａnd psychostimulants, ａnd are deficient in affective ａnd autonomic disorders. In rat brain, noradrenaline transporter is expressed in noradrenergic neuronal somata, axons ａnd dendrites, ａnd hippocampus ａnd cortex, but is absent from epinephrine- ａnd dopamine-containing neurons. At least 13 genetic variations have been reported in the noradrenaline transporter protein that affect noradrenaline re-uptake ａnd concentrations in cerebrospinal fluid in humans. The association between these genetic variations in noradrenaline transporters ａnd several psychiatric ａnd cardiovascular disorders is just emerging. Recently, a single amino acid mutation （hNET-A457P） showed deficiency in noradrenaline transport in an orthostatic intolerance patient. Noradrenaline transporter protein consists of 617 amino acids ａnd has 12 trans-membrane domains, a characteristic feature of many membrane associated solute transporters.Subunit : Interacts with RHOA in its GTP- ａnd GDP-bound states, ａnd with CDC42 in its GTP-bound state. Interacts with the PDZ 1 domain of BAIAP1.Subcellular Location : Cytoplasm. Nucleus.Tissue Specificity : Widely expressed.Similarity : Contains 1 DH （DBL-homology） domain.Contains 1 PH domain.