Phospho-NPM (Thr199)磷酸化核仁磷酸蛋白抗体

本公司经销Phospho-NPM （Thr199），磷酸化核仁磷酸蛋白抗体，克隆类型为polyclonal，宿主来源是Rabbit，Phospho-NPM （Thr199）磷酸化核仁磷酸蛋白抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-3310R
英文名称：Anti-Phospho-NPM （Thr199）
中文名称：磷酸化核仁磷酸蛋白抗体
其他名称：名NMP1; NO38; NPM 1; NPM; NPM1; Nucleolar Phosphoprotein B23; Nucleolar protein NO38; Nucleophosmin/B23.2; Nucleoplasmin Family Member 1; Numatrin; TRK fused gene; B23; MGC104254.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 38kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：Nucleophosmin （NPM） also called B23, nutramin ａnd NO38 is a ubiquitously expressed phosphoprotein involved in ribosome assembly/transport, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication, ａnd regulation of p53. It is involved in the acute response of mammalian cells to environmental stress, such as UV rays. NPM continuously shuttles between the nucleus ａnd cytoplasm. It has been shown to bind nucleic acid, prevent protein aggregation via its chaperone activities, protect enzymes during thermal denaturation, ａnd facilitate renaturation of chemically denatured proteins. In its cellular structure role, there is evidence suggesting NPM is associated with the centrosome. It is the substrate of CDK2/cyclin E during duplication of centrosomes （cellular division）. Because of NPM gene interaction with several tumor-associated chromosome translocations, NPM is thought to be a portion of several fusion proteins: NPM-ALK, NPM-RAR, ａnd NPM-MLF1. While it is not thought to be part of the transforming potential of these fusion proteins, it is believed to act as the interface for oligomerization ａnd oncogenic conversion of these tumor promoting fusion proteins.核仁磷酸蛋白（nucleophosmin）是雌激素调控的一种核仁蛋白， Nucleophosmin（又称为NPM、B23、Numatrin、NO38）位于核仁的颗粒区,与其他一些核蛋白如C23、P120等可相互作用。 NPM可以在细胞核与细胞浆之间穿梭,其定位受细胞周期及一些细胞物的影响。NPM基因在多种人类肿瘤中过表达,因此被公认为肿瘤标志物和癌基因.后来研究发现NPM也具有YZ肿瘤的功能,它的缺失、突变甚至重排与多种肿瘤的发生密切相关.