本公司经销Phospho-NMDAR1(Ser897),磷酸化谷氨酸受体1抗体,克隆类型为polyclonal,宿主来源是Rabbit,Phospho-NMDAR1(Ser897)磷酸化谷氨酸受体1抗体可应用于WB、elisa、IP、IF、IHC等实验,欢迎垂询订购!
本公司经销Phospho-NMDAR1(Ser897),磷酸化谷氨酸受体1抗体,克隆类型为polyclonal,宿主来源是Rabbit,Phospho-NMDAR1(Ser897)磷酸化谷氨酸受体1抗体可应用于WB、elisa、IP、IF、IHC等实验,欢迎垂询订购!
货号:BY-3903R
英文名称:Anti-Phospho-NMDAR1(Ser897)
中文名称:磷酸化谷氨酸受体1抗体
其他名称:名N-Methyl-d-Asprtate receptor 1; GRIN1; NMDA1; NMDAR1; NR1; Glutamate [NMDA] receptor subunit zeta 1; Glutamate receptor ionotropic N methyl D aspartate 1; Grin 1; Grin1; N methyl D aspartate receptor channel; N-methyl-D-aspartate receptor; N-methyl-D-aspartate receptor subunit NR1; NMD-R1; NMDA 1; NMDA NR1; NMDA R1; NMDA receptor 1; NMDA1; NMDAR 1; NMDAR; Nmdar1; NR 1; NR1.
抗体来源:Rabbit
克隆类型:polyclonal
蛋白分子量:predicted molecular weight: 105kDa
纯化方法:affinity purified by Protein A
交叉反应:hu, mo, rat, chk
产品介绍:Neuronal MarkerThe protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.Function : NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.Subunit : Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ (By similarity). Interacts with LRFN1 and LRFN2 (By similarity). Interacts with MYZAP.Subcellular Location : Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.Post-translational modifications : NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity.DISEASE : Defects in GRIN1 are the cause of mental retardation autosomal dominant type 8 (MRD8) [MIM:614254]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.Similarity : Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.神经细胞标志物(NMDAR1)N-甲基-D-天门冬氨酸受体(NMDAR)是兴奋性氨基酸受体亚型之一,是由NMDAR1与不同的NMDAR2亚基组成的异聚体。NMDAR1又称GluR1 (Glutamate Receptor 1)近年实验研究发现,许多NMDAR拮抗药均具有镇痛活性,表明NMDAR在痛觉传递中具有重要作用,这为新型镇痛药的研究开发提供了新的作用靶点。